Activation of the aryl hydrocarbon receptor is the major toxic mode of action of an organic extract of a reference urban dust particulate matter mixture: the role of …
Z Andrysík, J Vondráček, S Marvanová… - Mutation Research …, 2011 - Elsevier
Many of the toxic and carcinogenic effects of urban air pollution have been linked to
polycyclic aromatic hydrocarbons (PAHs) adsorbed to airborne particulate matter (PM). The …
polycyclic aromatic hydrocarbons (PAHs) adsorbed to airborne particulate matter (PM). The …
Environmental six-ring polycyclic aromatic hydrocarbons are potent inducers of the AhR-dependent signaling in human cells
J Vondráček, K Pěnčíková, M Ciganek, J Pivnička… - Environmental …, 2020 - Elsevier
The toxicities of many environmental polycyclic aromatic hydrocarbons (PAHs), in particular
those of high-molecular-weight PAHs (with MW higher than 300), remain poorly …
those of high-molecular-weight PAHs (with MW higher than 300), remain poorly …
In vitro genotoxicity of PAH mixtures and organic extract from urban air particles: Part II: Human cell lines
O Sevastyanova, B Binkova, J Topinka, RJ Sram… - Mutation Research …, 2007 - Elsevier
Principal aims of this study were at first, to find a relevant human derived cell line to
investigate the genotoxic potential of PAH-containing complex mixtures and second, to use …
investigate the genotoxic potential of PAH-containing complex mixtures and second, to use …
[HTML][HTML] Genotoxicity but not the AhR-mediated activity of PAHs is inhibited by other components of complex mixtures of ambient air pollutants
H Líbalová, S Krčková, K Uhlířová, A Milcová… - Toxicology letters, 2014 - Elsevier
In this study, we compared the genotoxicity and aryl hydrocarbon receptor (AhR)-dependent
transcriptional changes of selected target genes in human lung epithelial A549 cells …
transcriptional changes of selected target genes in human lung epithelial A549 cells …
Oxidative damage induced by carcinogenic polycyclic aromatic hydrocarbons and organic extracts from urban air particulate matter
K Hanzalova, P Rossner Jr, RJ Sram - Mutation Research/Genetic …, 2010 - Elsevier
We investigated the role of oxidative damage in the mechanism of action of selected
individual carcinogenic PAHs (c-PAHs: benzo [a] pyrene, B [a] P; dibenzo [a, l] pyrene, DB …
individual carcinogenic PAHs (c-PAHs: benzo [a] pyrene, B [a] P; dibenzo [a, l] pyrene, DB …
Altered gene expression patterns in MCF-7 cells induced by the urban dust particulate complex mixture standard reference material 1649a
B Mahadevan, C Keshava, T Musafia-Jeknic, A Pecaj… - Cancer research, 2005 - AACR
Human exposures to polycyclic aromatic hydrocarbon (PAH) occur in complex mixtures.
Here, gene expression patterns were investigated using standard reference material (SRM) …
Here, gene expression patterns were investigated using standard reference material (SRM) …
Aryl hydrocarbon receptor plays a significant role in mediating airborne particulate-induced carcinogenesis in mice
Y Matsumoto, F Ide, R Kishi, T Akutagawa… - … science & technology, 2007 - ACS Publications
Urban particulate air pollution is associated with an increased incidence of cancers, and
especially lung cancer. Organic extracts of airborne particulate matter (APM) cause cancer …
especially lung cancer. Organic extracts of airborne particulate matter (APM) cause cancer …
Urban dust particulate matter alters PAH-induced carcinogenesis by inhibition of CYP1A1 and CYP1B1
LA Courter, T Musafia-Jeknic, K Fischer… - Toxicological …, 2007 - academic.oup.com
The polycyclic aromatic hydrocarbons (PAHs) benzo [a] pyrene (B [a] P) and dibenzo [a, l]
pyrene (DB [a, l] P) are well-studied environmental carcinogens, however, their potency …
pyrene (DB [a, l] P) are well-studied environmental carcinogens, however, their potency …
Aryl hydrocarbon receptor-mediated activity of atmospheric particulate matter from an urban and a rural site in Switzerland
D Wenger, AC Gerecke, NV Heeb, C Hueglin… - Atmospheric …, 2009 - Elsevier
Atmospheric particulate matter (PM) is an air-suspended mixture of solid and liquid particles
that vary in size, shape, and chemical composition. Long-term exposure to elevated …
that vary in size, shape, and chemical composition. Long-term exposure to elevated …
Ultrafine particles are not major carriers of carcinogenic PAHs and their genotoxicity in size-segregated aerosols
J Topinka, A Milcova, J Schmuczerova… - … /Genetic Toxicology and …, 2013 - Elsevier
Some studies suggest that genotoxic effects of combustion-related aerosols are induced by
carcinogenic polycyclic aromatic hydrocarbons (c-PAHs) and their derivatives, which are …
carcinogenic polycyclic aromatic hydrocarbons (c-PAHs) and their derivatives, which are …