Research into the natural aging process of platelets has garnered much research interest in
recent years, and there have long been associations drawn between the proportion of newly …

Although there have been advances dissecting the molecular mechanisms regarding aging-
related changes in platelets, many knowledge gaps still remain. Studies filling these gaps …

Background Platelets circulate in the blood of healthy individuals for approximately 7–10
days regulated by finely balanced processes of production and destruction. As platelets are …

Platelet ageing is an area of research which has gained much interest in recent years.
Newly formed platelets, often referred to as reticulated platelets, young platelets or immature …

There are clear age-related changes in platelet count and function, driven by changes in
hematopoietic tissue, the composition of the blood and vascular health. Platelet count …

Aging is associated with an increased incidence of cardiovascular disease and thrombosis.
Platelets play a major role in maintaining hemostasis and in thrombus formation, making …

Hansjörg Schwertz and Matthew T. Rondina www. aging-us. com AGING 2018, Vol. 10, No.
11 www. aging-us. com 3054 AGING functionally serves to regulate platelet activation and …

Proteins are the chief effectors of cell function. The total complement of proteins present in a
cell at any given time is known as its proteome, which is under regulatory control and varies …

Introduction: Alzheimer's disease (AD) and aging are associated with platelet hyperactivity.
However, the mechanisms underlying abnormal platelet function in AD and aging are yet …

The proportion of young platelets, also known as newly formed or reticulated, within the
overall platelet population has been clinically correlated with adverse cardiovascular …