Controlled delivery of single or multiple antigens in tolerogenic nanoparticles using peptide-polymer bioconjugates
RM Pearson, LM Casey, KR Hughes, LZ Wang… - Molecular Therapy, 2017 - cell.com
Polymeric nanoparticles (NPs) have demonstrated their potential to induce antigen (Ag)-
specific immunological tolerance in multiple immune models and are at various stages of …
specific immunological tolerance in multiple immune models and are at various stages of …
Development of protein–polymer conjugate nanoparticles for modulation of dendritic cell phenotype and Antigen-Specific CD4 T cell responses
BL Scotland, AL Cottingham, JJM Lasola… - ACS Applied Polymer …, 2023 - ACS Publications
Polymeric nanoparticles (NPs) composed of poly (lactic-co-glycolic acid)(PLGA) have found
success in modulating antigen (Ag)-specific T cell responses for the treatment multiple …
success in modulating antigen (Ag)-specific T cell responses for the treatment multiple …
An antigen-encapsulating nanoparticle platform for TH1/17 immune tolerance therapy
DP McCarthy, JWT Yap, CT Harp, WK Song… - … , Biology and Medicine, 2017 - Elsevier
Tolerogenic nanoparticles (NPs) are rapidly being developed as specific immunotherapies
to treat autoimmune disease. However, many NP-based therapies conjugate antigen (Ag) …
to treat autoimmune disease. However, many NP-based therapies conjugate antigen (Ag) …
Conjugation of Transforming Growth Factor Beta to Antigen-Loaded Poly(lactide-co-glycolide) Nanoparticles Enhances Efficiency of Antigen-Specific Tolerance
LM Casey, RM Pearson, KR Hughes… - Bioconjugate …, 2017 - ACS Publications
Current strategies for treating autoimmunity involve the administration of broad-acting
immunosuppressive agents that impair healthy immunity. Intravenous (iv) administration of …
immunosuppressive agents that impair healthy immunity. Intravenous (iv) administration of …
Peptide-conjugated nanoparticles reduce positive co-stimulatory expression and T cell activity to induce tolerance
Targeted approaches to treat autoimmune diseases would improve upon current therapies
that broadly suppress the immune system and lead to detrimental side effects. Antigen …
that broadly suppress the immune system and lead to detrimental side effects. Antigen …
Nanoparticle dose and antigen loading attenuate antigen‐specific T‐cell responses
Immune‐mediated hypersensitivities such as autoimmunity, allergy, and allogeneic graft
rejection are treated with therapeutics that suppress the immune system, and the lack of …
rejection are treated with therapeutics that suppress the immune system, and the lack of …
A biodegradable nanoparticle platform for the induction of antigen-specific immune tolerance for treatment of autoimmune disease
Z Hunter, DP McCarthy, WT Yap, CT Harp, DR Getts… - ACS …, 2014 - ACS Publications
Targeted immune tolerance is a coveted therapy for the treatment of a variety of autoimmune
diseases, as current treatment options often involve nonspecific immunosuppression …
diseases, as current treatment options often involve nonspecific immunosuppression …
Targeted immunomodulation using antigen‐conjugated nanoparticles
DP McCarthy, ZN Hunter, B Chackerian… - Wiley …, 2014 - Wiley Online Library
The growing prevalence of nanotechnology in the fields of biology, medicine, and the
pharmaceutical industry is confounded by the relatively small amount of data on the impact …
pharmaceutical industry is confounded by the relatively small amount of data on the impact …
PEGylation enables subcutaneously administered nanoparticles to induce antigen-specific immune tolerance
The development of nanomaterials to induce antigen-specific immune tolerance has shown
promise for treating autoimmune diseases. While PEGylation has been widely used to …
promise for treating autoimmune diseases. While PEGylation has been widely used to …
Engineering biodegradable guanidyl-decorated PEG-PCL nanoparticles as robust exogenous activators of DCs and antigen cross-presentation
P Li, H Song, H Zhang, P Yang, C Zhang, P Huang… - Nanoscale, 2017 - pubs.rsc.org
Nanoparticles (NPs)-based adjuvants are attracting much attention in the development of
vaccines. Previously, we reported a type of guanidyl-decorated polymeric NPs used as …
vaccines. Previously, we reported a type of guanidyl-decorated polymeric NPs used as …
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