Controlled delivery of single or multiple antigens in tolerogenic nanoparticles using peptide-polymer bioconjugates

RM Pearson, LM Casey, KR Hughes, LZ Wang… - Molecular Therapy, 2017 - cell.com
Polymeric nanoparticles (NPs) have demonstrated their potential to induce antigen (Ag)-
specific immunological tolerance in multiple immune models and are at various stages of …

Development of protein–polymer conjugate nanoparticles for modulation of dendritic cell phenotype and Antigen-Specific CD4 T cell responses

BL Scotland, AL Cottingham, JJM Lasola… - ACS Applied Polymer …, 2023 - ACS Publications
Polymeric nanoparticles (NPs) composed of poly (lactic-co-glycolic acid)(PLGA) have found
success in modulating antigen (Ag)-specific T cell responses for the treatment multiple …

An antigen-encapsulating nanoparticle platform for TH1/17 immune tolerance therapy

DP McCarthy, JWT Yap, CT Harp, WK Song… - … , Biology and Medicine, 2017 - Elsevier
Tolerogenic nanoparticles (NPs) are rapidly being developed as specific immunotherapies
to treat autoimmune disease. However, many NP-based therapies conjugate antigen (Ag) …

Conjugation of Transforming Growth Factor Beta to Antigen-Loaded Poly(lactide-co-glycolide) Nanoparticles Enhances Efficiency of Antigen-Specific Tolerance

LM Casey, RM Pearson, KR Hughes… - Bioconjugate …, 2017 - ACS Publications
Current strategies for treating autoimmunity involve the administration of broad-acting
immunosuppressive agents that impair healthy immunity. Intravenous (iv) administration of …

Peptide-conjugated nanoparticles reduce positive co-stimulatory expression and T cell activity to induce tolerance

R Kuo, E Saito, SD Miller, LD Shea - Molecular Therapy, 2017 - cell.com
Targeted approaches to treat autoimmune diseases would improve upon current therapies
that broadly suppress the immune system and lead to detrimental side effects. Antigen …

Nanoparticle dose and antigen loading attenuate antigen‐specific T‐cell responses

LM Casey, JT Decker, JR Podojil, L Rad… - Biotechnology and …, 2023 - Wiley Online Library
Immune‐mediated hypersensitivities such as autoimmunity, allergy, and allogeneic graft
rejection are treated with therapeutics that suppress the immune system, and the lack of …

A biodegradable nanoparticle platform for the induction of antigen-specific immune tolerance for treatment of autoimmune disease

Z Hunter, DP McCarthy, WT Yap, CT Harp, DR Getts… - ACS …, 2014 - ACS Publications
Targeted immune tolerance is a coveted therapy for the treatment of a variety of autoimmune
diseases, as current treatment options often involve nonspecific immunosuppression …

Targeted immunomodulation using antigen‐conjugated nanoparticles

DP McCarthy, ZN Hunter, B Chackerian… - Wiley …, 2014 - Wiley Online Library
The growing prevalence of nanotechnology in the fields of biology, medicine, and the
pharmaceutical industry is confounded by the relatively small amount of data on the impact …

PEGylation enables subcutaneously administered nanoparticles to induce antigen-specific immune tolerance

PY Li, F Bearoff, P Zhu, Z Fan, Y Zhu, M Fan… - Journal of controlled …, 2021 - Elsevier
The development of nanomaterials to induce antigen-specific immune tolerance has shown
promise for treating autoimmune diseases. While PEGylation has been widely used to …

Engineering biodegradable guanidyl-decorated PEG-PCL nanoparticles as robust exogenous activators of DCs and antigen cross-presentation

P Li, H Song, H Zhang, P Yang, C Zhang, P Huang… - Nanoscale, 2017 - pubs.rsc.org
Nanoparticles (NPs)-based adjuvants are attracting much attention in the development of
vaccines. Previously, we reported a type of guanidyl-decorated polymeric NPs used as …