Antidepressant medications generally are considered to have a delayed onset of action;
however, recent evidence is beginning to challenge this conventional wisdom. Meta …

Although antidepressant medications are effective in approximately 70% of patients with
major depressive disorder, they have a delayed onset of therapeutic effect. This latency is …

Background: For years, investigators have tried to determine the speed of onset of
antidepressant drugs. Claims that particular drugs may produce a faster response in patients …

In standard drug trials comparing antidepressants with placebo, a period of typically 3 weeks
is required before formal statistical significance between treatments is achieved. This delay …

OBJECTIVE: The primary objective of this article is to review the literature regarding the
speed of response to antidepressant drugs and potential strategies to accelerate the …

The onset of action of antidepressant drugs was investigated on the basis of two
independent, multicenter, double-blind studies, comparing amitriptyline (N= 120) …

Objectives: It has long been thought that there is a delay of several weeks before a true
antidepressant effect occurs, although this theory has increasingly come into question. The …

Although various published clinical studies have suggested that some antidepressants may
have a more rapid onset of therapeutic effect than others, none of these trials was …

Conventional repeated measurements analysis of variance suggests that response to
antidepressants is slow, and that differences between antidepressants and placebo do not …

The issues of timing in antidepressant treatment are of great theoretical and practical
relevance, even more so since recent meta-analyses yielded no evidence for a specific …