Chlamydiaphage φCPG1 Capsid Protein Vp1 Inhibits Chlamydia trachomatis Growth via the Mitogen-Activated Protein Kinase Pathway

Y Guo, R Guo, Q Zhou, C Sun, X Zhang, Y Liu, Q Liu - Viruses, 2016 - mdpi.com
Chlamydia trachomatis is the most common cause of curable bacterial sexually transmitted
infections worldwide. Although the pathogen is well established, the pathogenic …

Significant role of IL-1 signaling, but limited role of inflammasome activation, in oviduct pathology during Chlamydia muridarum genital infection

UM Nagarajan, JD Sikes, L Yeruva… - The Journal of …, 2012 - journals.aai.org
IL-1β has been implicated in the development of oviduct pathology during Chlamydia
muridarum genital infection in the mouse model. The goal of this study was to characterize …

Chlamydia trachomatis plasmid-encoding Pgp3 protein induces secretion of distinct inflammatory signatures from HeLa cervical epithelial cells

HC Cheong, YY Cheok, YT Chan, TF Tang… - BMC microbiology, 2023 - Springer
Abstract Background Genital Chlamydia trachomatis infection is the most common bacterial
sexual transmitted disease that causes severe complications including pelvic inflammatory …

IL-17A synergizes with IFN-γ to upregulate iNOS and NO production and inhibit chlamydial growth

Y Zhang, H Wang, J Ren, X Tang, Y Jing, D Xing… - PloS one, 2012 - journals.plos.org
IFN-γ-mediated inducible nitric oxide synthase (iNOS) expression is critical for controlling
chlamydial infection through microbicidal nitric oxide (NO) production. Interleukin-17A (IL …

Significant Roles Played by IL-10 in Chlamydia Infections

H Hakimi, M Zare-Bidaki, N Zainodini, S Assar… - Inflammation, 2014 - Springer
Chlamydia species are obligate intracellular parasites which cause usually asymptomatic
genital tract infections and also are associated with several complications. Previous studies …

Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome

X He, S Mekasha, N Mavrogiorgos… - The Journal of …, 2010 - journals.aai.org
Chlamydia pneumoniae is a common respiratory pathogen associated with atypical
pneumonia, and it has been suggested as a trigger or promoter of several chronic …

Transcription factor complex AP‐1 mediates inflammation initiated by Chlamydia pneumoniae infection

A Wang, M Al‐Kuhlani, SC Johnston… - Cellular …, 2013 - Wiley Online Library
C hlamydia pneumoniae is responsible for a high prevalence of respiratory infections
worldwide and has been implicated in atherosclerosis. Inflammation is regulated by …

STAT3-mediated TLR2/4 pathway upregulation in an IFN-gamma-induced Chlamydia trachomatis persistent infection model

P Yu, L Xiao, L Lin, L Tang, C Chen… - FEMS Pathogens and …, 2016 - academic.oup.com
Inflammatory pathological injury caused by Chlamydia trachomatis persistent infection could
lead to a variety of urogenital tract diseases. By comparing the cytokine production and PRR …

Chlamydia psittaci Plasmid-Encoded CPSIT_P7 Elicits Inflammatory Response in Human Monocytes via TLR4/Mal/MyD88/NF-κB Signaling Pathway

Q Chen, Y Li, X Yan, Z Sun, C Wang, S Liu… - Frontiers in …, 2020 - frontiersin.org
The chlamydial plasmid, an essential virulence factor, encodes plasmid proteins that play
important roles in chlamydial infection and the corresponding immune response. However …

[HTML][HTML] Pgp3 protein of Chlamydia trachomatis inhibits apoptosis via HO-1 upregulation mediated by PI3K/Akt activation

M Shu, J Bu, W Lei, L Chen, Z Zhou, C Lu, C Chen… - Microbial …, 2023 - Elsevier
As an obligate intracellular pathogen, Chlamydia trachomatis assumes various strategies to
inhibit host cells apoptosis, thereby providing a suitable intracellular environment to ensure …