Tumorigenesis has been considered to be as a result of abnormal cell-cell communication.
Although it is known that the tumor-associated microenvironment often becomes hypoxic …

Cancer is a major cause of death, and considerable research has been done to/determine
factors for its diagnosis and prognosis. As cancer tumor cells rapidly/reproduce, they use up …

The tumor microenvironment, composed of non‐cancer cells and their stroma, has become
recognized as a major factor influencing the growth of cancer. The microenvironment has …

An increasing body of research indicates that stroma surrounding cancer cells plays an
important role in the development and subsequent behavior of the tumor. Studies using a …

The majority of studies of neoplastic transformation have focused attention on events that
occur within transformed cells. These cell autonomous events result in the disruption of …

Solid tumors are composed of malignant parenchymal cells embedded in nonneoplastic
stroma. A large body of evidence emphasizes that the actual biological behavior of the given …

Stromal cells in the vicinity of tumour cells are not an inert component of an organ. Cancer
cells induce the fibroblasts of the surrounding connective tissue to develop into carcinoma …

The role of stromal cells in the tumor microenvironment has been extensively characterized.
We and others have shown that stromal cells may participate in several steps of the …

Tumorigenesis is a complex multistep process in which a plethora of tumor and stromal cells
play important roles. From this point of view, the biology of a tumor can be elucidated by …

Solid tumors are organ-like entities. In addition to neoplastic cells, they consist of non-
transformed host stromal cells such as endothelial cells, fibroblasts and inflammatory cells …