Abstract 3515 The recruitment of host vasculature and the infiltrative behaviour of gliomas
underscore the significance of tumor-stroma interactions in brain tumor pathogenesis …

A lot of effort has been done to study how cancer cells react to low-oxygen tension, a
condition known as hypoxia. Indeed, abnormal and dysfunctional blood vessels in the tumor …

Introduction: Cancers exist within a complex microenvironment populated by diverse cell
types within a protein-rich extracellular matrix. It is becoming increasingly apparent that …

Numerous studies have demonstrated that the tumor microenvironment not only responds to
and supports carcinogenesis, but also actively contributes to tumor initiation, progression …

Mesenchymal stromal cells (MSCs) have been suggested as a source of carcinoma-
associated fibroblasts (CAFs) within the tumor stroma. CAFs are known to support tumor …

The tumor microenvironment is crucial in the initiation and progression of cancers. The
interplay between cancer cells and the surrounding stroma shapes the tumor biology and …

Identification of gene expression mechanisms began with works on embryonic induction.
The same mechanism of cell-cell interactions also contributes to the process of …

It is widely accepted that the development of carcinoma is not only due to somatic mutations
in epithelial cells but also is influenced by the tumor microenvironment ie the stroma. The …

Emerging studies have begun to demonstrate that reprogrammed stromal cells play pivotal
roles in tumor growth, metastasis, and resistance to therapy. However, the contribution of …

The major cellular components of tumor microenvironment, referred to as the cancer stroma,
are composed of cancer-associated fibroblasts that support tumor epithelial growth, invasion …