The complex cellular tumor micro (environment) comprises immunocompetent and
inflammatory cells, endothelial cells and fibroblasts. All these cell types may influence the …

Carcinomas are composed of neoplastic epithelial cells, which form the heart of the tumor,
as well as a variety of mesenchymal cell types and extracellular matrix components that …

INTRODUCTION: The crosstalk between tumor cells and surrounding stromal fibroblasts is
now considered crucial for cancer progression, particularly in invasive tumors such as lung …

Oncogene activation and tumor-suppressor gene inactivation are considered as the main
causes driving the transformation of normal somatic cells into malignant tumor cells. Cancer …

Abstract The Epithelial-Stromal Interactions Workshop was organized with the purpose of
accelerating progress in understanding the interrelationship between tumor cells and their …

Solid tumours are multi-cellular tissues comprised of tumour cells and stromal cells,
including fibroblasts, endothelial cells and inflammatory cells. When a cancer cell …

Successful establishment of a tumour relies on a cascade of interactions between cancer
cells and stromal cells within an evolving microenvironment. Both immune and nonimmune …

It is widely believed that the development of the most common tumour types or 'carcinomas',
is triggered by somatic mutations in epithelial cells (Lengauer et al 1998). It is thought that …

Recent advances in tumor biology have identified the stroma as an important regulator of
carcinogenesis and potentially a valuable therapeutic target. While however the fact that by …

Tumour-stroma interaction plays a significant role for malignant growth. Here, we analyzed
the functional and molecular sequels of interaction in a non-contact co-culture model …