The list of pathophysiological conditions that are associated with the overproduction of
superoxide anions expands every day. The most exciting realization is that there seems to …

Reactive oxygen species, such as superoxide radicals, are thought to underlie the
pathogenesis of various diseases. Almost 3 to 10% of the oxygen utilized by tissues is …

Twenty years ago, the enzyme superoxide dismutase which uses the superoxide radical
anion as its specific substrate was reported. With this discovery was born a new scientific …

In many pathological situations, tissue damage is caused by cellular generation of
superoxide free radicals (O2-). These active species are generated during post-ischemic …

Oxidative stress results from an oxidant/antioxidant imbalance: an excess of oxidants
relative to the antioxidant capacity. Recent evidence strongly suggests that oxidant stress …

Free radicals and other oxidants are critical determinants of the cellular signaling pathways
involved in the pathogenesis of several human diseases including inflammatory diseases …

Overproduction of the reactive oxygen species (ROS) superoxide (O2−) and hydrogen
peroxide (H2O2) are increasingly implicated in human disease and aging. ROS are also …

In recent years, oxidative stress has been implicated in a variety of degenerative processes,
diseases, and syndromes. Some of these include atherosclerosis, myocardial infarction …

Formulations of antioxidant enzymes, superoxide dismutase 1 (SOD1, also known as Cu/Zn
SOD) and catalase were prepared by electrostatic coupling of enzymes with cationic block …

Without a doubt PEG–SOD has been the enzyme most studied in PEGylation. One can say
that it represents the preferred model to assess chemistries for PEG activation, analytical …