Hyperglycemia/oxidative stress has been implicated in the initiation and progression of
diabetic complications while the components of Keap1/Nrf2/ARE signaling are being …

Diabetes mellitus (DM) is one of the most debilitating chronic diseases worldwide, with
increased prevalence and incidence. In addition to its macrovascular damage, through its …

Despite improvements in awareness and treatment of type II diabetes mellitus (TIIDM), this
disease remains a major source of morbidity and mortality worldwide, and prevalence …

The pathogenic processes involving in the development of diabetes range from autoimmune
destruction of pancreatic β-cells with consequent insulin deficiency to abnormalities that …

Background: Nuclear factor erythroid 2-related factor 2 (NRF2) is a critical transcription factor
for the antioxidative stress response and it activates a variety of cytoprotective genes related …

Diabetes is the major cause of chronic kidney disease worldwide (1) with treatment options
focused primarily on glucose control, blood pressure, lipid lowering, and the blockade of the …

Western lifestyle contributes to an overt increase in the prevalence of metabolic anomalies
including diabetes mellitus (DM) and obesity. Prevalence of DM is rapidly growing …

Diabetic nephropathy (DN), a progressive kidney disease afflicts more than 20 and up to
40% of the diabetic population and it is characterized by persistent microalbuminuria …

Oxidative stress is a major component of cell damage and cell fat, and as such, it occupies a
central position in the pathogenesis of metabolic disease. Nuclear factor-erythroid-derived 2 …

Endothelial dysfunction (ED) is a key event in the onset and progression of vascular
complications associated with diabetes. Regulation of endothelial function and the …