Pulmonary embolism may cause pulmonary hypertension by mechanical obstruction, which
might be amplified by vasoconstriction induced by serotonin released from the emboli. The …

Two distinct binding sites for serotonin have been identified in brain tissue and labeled 5-HT
1 and 5-HT 2 binding sites. The receptor mediating contractions of several types of vascular …

Ketanserin is a serotonin (S,) Mocker that reduces blood pressure (BP) in patients with
essential hypertension preferentially by a reduction of peripheral vascular resistance. Heart …

Serotonin is an important neurohormonal factor that has been implicated in cardiovascular
function. It can regulate vascular tone, act directly on cardiomyocytes and stimulate …

Cardiovascular diseases and depression are significant health burdens and increasing
evidence suggests a causal relationship between them. The incidence of depression among …

The vasoconstrictor effects of serotonin can be explained by (a) activation of serotonergic
receptors on vascular smooth muscle,(b) activation, directly or indirectly, of postjunctional …

LY53857 was a potent antagonist of vascular contraction to serotonin, which is mediated by
serotonergic (5-HT2) receptors, with a dissociation constant in vitro of 5.4 X 10 (-11) M …

This paper reviews the role of central serotonin-containing neurons in the control of blood
pressure. Central serotonin nerves have their cell bodies in the brainstem in a number of …

Several members of the newly discovered ketanserin series of specific, pure and potent 5-
HT2-antagonists are essential tools for studying the role of serotonin (5-HT) in a wide variety …

5-Hydroxytryptamine (5-HT, serotonin) is a regulator of smooth muscle in the cardiovascular
system and the gastrointestinal tract, an enhancer of platelet aggregation, and a …