Serotonin (5-hydroxytryptamine, 5-HT) is one of the newer neurotransmitters to be
recognized for physiological importance. What is meant by"'newer''is that the majority of work …

Abstract Ketanserin (3× 40 mg daily) was administered during 6 weeks in 14 patients with
mild to moderate essential hypertension using a double-blind, placebo-controlled, crossover …

There is a current controversy in the literature about the mechanism of the hypotensive
action of the new 5-hydroxytryptamine antagonist, ketanserin. The advocates of the drug …

5-Hydroxytryptamine (5-HT), or serotonin, plays a crucial role as a neuromodulator and/or
neurotransmitter of several nervous system functions. Its actions are complex, and depend …

l-(m-Trifluoromethylphenyl) piperazine, a serotonin agonist, lowered blood pressure in
spontaneously hypertensive rats (SHR) at doses of 2 to 10 mg/kg sc A structurally related …

The function of the serotonin transporter (SERT) is to take up and release serotonin (5-
hydroxytyptamine (5-HT)) from cells and this function of SERT in the central nervous system …

Ketanserin is a 5-HT 2 receptor antagonist without partial agonist properties which also
possesses weak α 1-adrenoceptor antagonistic activity, which may explain its …

Serotonin-S 2 receptor binding sites have been labelled with several ligands such as [3 H]
spiperone,[3 H] lysergic acid diethylamide (LSD),[3 H] mianserin and [3 H] ketanserin, the …

The release of 5-hydroxytryptamine (5-HT) from aggregating platelets may trigger acute
vasospastic episodes of larger arteries, which can lead to tissue ischemia, particularly in the …

The cardiovascular effects of 5‐hydroxytryptamine (5‐HT), consisting of bradycardia or
tachycardia, hypotension or hypertension, and vasodilatation or vasoconstriction, are …