Abstract “Tumor-associated macrophages”(TAMs) form a significant cell population in
malignant tumors and contribute to tumor growth, metastasis, and neovascularization …

Introduction: Glioblastoma (GBM) is the deadliest primary malignant central nervous system
(CNS) tumor with a median overall survival of 15 months despite a very intensive therapeutic …

Tumor vascularization is a highly complex process that involves the interaction between
tumors and their surrounding stroma, as well as many distinct angiogenesis-regulating …

Simple Summary Macrophages are a specialized immune cell type found in both
invertebrates and vertebrates. Versatile in functionality, macrophages carry out important …

Tumor‐associated macrophages (TAMs) contribute substantially to the tumor mass of
gliomas and have been shown to play a major role in the creation of a tumor …

Glioblastoma (GB) is the most common and devastating form of brain cancer. Despite
conventional treatments, progression or recurrences are systematic. In recent years …

Simple Summary The tumor microenvironment is a complex network comprised of
neoplastic and a variety of immune cells, proteins, and inflammatory mediators. Previous …

Glioblastoma (GBM) is the most aggressive and deadliest of the primary brain tumors,
characterized by malignant growth, invasion into the brain parenchyma, and resistance to …

One of the functions of macrophages is to provide a defense mechanism against tumor cells.
In contrast, tumor-associated macrophages (TAMs), which represent the major inflammatory …

Simple Summary Since the targeting of a single pro-angiogenic factor fails to improve
oncological disease outcome, significant efforts have been made to identify new pro …