CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-
associated protein 9)-mediated genome editing holds remarkable promise for the treatment …

Gene editing tools are being rapidly developed, accelerating many areas of cell and gene
therapy research. Each successive gene editing technology promises increased efficacy …

Simple Summary We used PCR-generated small CRISPR constructs to edit two genes
(IDH2 and MYBL2) in hard-to-transfect hemopoietic cells, which are central to the …

Cancer is a genetic disease stemming from cumulative genetic/epigenetic aberrations.
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9-mediated …

There have been significant advances in understanding the genetics and molecular basis of
a number of hematological disorders in recent years, but clinical interventions, such as …

Leukemia represents a life adjusting, high mortality inducing health problem, accounting for
approximately 2.5% of all new cancer diagnoses and 3.1% of cancerrelated mortality …

Cancer, one of the leading causes of death, usually commences and progresses as a result
of a series of gene mutations and dysregulation of expression. With the development of …

The ability to precisely modify genomic sequences has always been a powerful tool for
determining the relationship between genotype and phenotype, and for targeted editing of …

The efficient site-specific DNA double-strand breaks (DSB) created by CRISPR/Cas9 has
revolutionized genome engineering and has great potential for editing hematopoietic …

Accessibility of hematopoietic stem cells (HSCs) for the manipulation and repopulation of the
blood and immune systems has placed them at the forefront of cell and gene therapy …