The prokaryotic adaptive immune system has clustered regularly interspaced short
palindromic repeat. CRISPR-associated protein (CRISPR-Cas) genome editing systems …

Highlights•We performed CRISPR/Cas9-mediated gene editing of a purified hematopoietic
stem cell (HSC) population.•Multiplex gene editing of HSCs causes clonal hematopoiesis …

Gene therapy represents a significant potential to revolutionize the field of hematology with
applications in correcting genetic mutations, generating cell lines and animal models, and …

Based on the tremendous progress of the understanding on the CRISPR‐Cas systems, the
application CRISPR/Cas technology has been extended into increasing scenarios in …

The CRISPR/Cas9 revolution has democratized access to genome editing in many
biological fields, including cancer research. Cancer results from the multistep accumulation …

Simple Summary Clustered regularly interspaced short palindromic repeats (CRISPR)-
CRISPR associated protein (Cas) 9 is a novel technology utilized to modify target genes …

Ever since its mechanism was discovered back in 2012, the CRISPR/Cas9 system have
revolutionized the field of genome editing. While at first it was seen as a therapeutic tool …

Cancer is one of the most leading causes of mortalities worldwide. It is caused by the
accumulation of genetic and epigenetic alterations in two types of genes: tumor suppressor …

The increasing burden on human malignant diseases became a major concern for
healthcare practitioners, that must deal with tumor relapse and the inability to efficiently treat …

Genetic manipulation is a powerful tool to establish the causal relationship between a
genetic lesion and a particular pathological phenotype. The rise of CRISPR/Cas9 genome …