[HTML][HTML] The Antiproliferative and Apoptotic Effects of Sirtinol, a Sirtuin Inhibitor on Human Lung Cancer Cells by Modulating Akt/β-Catenin-Foxo3A Axis
Y Fong, YC Lin, CY Wu, HMD Wang, LL Lin… - The Scientific World …, 2014 - hindawi.com
Sirtuins, NAD+-dependent deacetylases, could target both histones and nonhistone proteins
in mammalian cells. Sirt1 is the major sirtuin and has been shown to involve various cellular …
in mammalian cells. Sirt1 is the major sirtuin and has been shown to involve various cellular …
[HTML][HTML] Silencing Sirtuin 6 induces cell cycle arrest and apoptosis in non-small cell lung cancer cell lines
V Krishnamoorthy, R Vilwanathan - Genomics, 2020 - Elsevier
Abstract Sirtuins (SIRT1–7), are NAD-dependent deacetylases and ADP-ribosyl
transferases, plays a major part in carcinogenesis. The previous report suggests that in …
transferases, plays a major part in carcinogenesis. The previous report suggests that in …
MHY2245, a sirtuin inhibitor, induces cell cycle arrest and apoptosis in HCT116 human colorectal cancer cells
YJ Kang, JY Jang, YH Kwon, JH Lee, S Lee… - International Journal of …, 2022 - mdpi.com
Sirtuins (SIRTs), which are nicotinamide adenine dinucleotide-dependent class III histone
deacetylases, regulate cell division, survival, and senescence. Although sirtinol, a synthetic …
deacetylases, regulate cell division, survival, and senescence. Although sirtinol, a synthetic …
[HTML][HTML] Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells
J Wang, TH Kim, MY Ahn, J Lee… - International …, 2012 - spandidos-publications.com
Abstract Sirtuins (SIRTs), NAD+-dependent class III histone deacetylases (HDACs), play an
important role in the regulation of cell division, survival and senescence. Although a number …
important role in the regulation of cell division, survival and senescence. Although a number …
Metformin and tenovin‐6 synergistically induces apoptosis through LKB1‐independent SIRT1 down‐regulation in non‐small cell lung cancer cells
BB Lee, Y Kim, D Kim, EY Cho, J Han… - Journal of cellular …, 2019 - Wiley Online Library
Abstract Sirtuin 1 (SIRT1) is known to play a role in a variety of tumorigenesis processes by
deacetylating histone and non‐histone proteins; however, antitumour effects by suppressing …
deacetylating histone and non‐histone proteins; however, antitumour effects by suppressing …
[HTML][HTML] MHY2251, a new SIRT1 inhibitor, induces apoptosis via JNK/p53 pathway in HCT116 human colorectal cancer cells
YJ Kang, YH Kwon, JY Jang, JH Lee… - Biomolecules & …, 2023 - ncbi.nlm.nih.gov
Sirtuins (SIRTs) belong to the nicotinamide adenine dinucleotide (NAD+)-dependent class III
histone deacetylase family. They are key regulators of cellular and physiological processes …
histone deacetylase family. They are key regulators of cellular and physiological processes …
[HTML][HTML] The apoptotic effects of sirtuin1 inhibitor on the MCF-7 and MRC-5 cell lines
MN Dastjerdi, MR Salahshoor, M Mardani… - Research in …, 2013 - ncbi.nlm.nih.gov
Abstract Sirtuin1 (SIRT1) is an enzyme that deacetylates histones and several nonhistone
proteins including p53 during stress and plays an important role in the survival of tumor …
proteins including p53 during stress and plays an important role in the survival of tumor …
[HTML][HTML] Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathway
NN Tao, HZ Zhou, H Tang, XF Cai, WL Zhang, JH Ren… - Oncotarget, 2016 - ncbi.nlm.nih.gov
SIRT3, a class III histone deacetylase, has been implicated in various cancers as a novel
therapeutic target. In hepatocellular carcinoma (HCC), we previously reported that SIRT3 …
therapeutic target. In hepatocellular carcinoma (HCC), we previously reported that SIRT3 …
Sirt2 suppresses glioma cell growth through targeting NF-κB–miR-21 axis
Y Li, D Dai, Q Lu, M Fei, M Li, X Wu - Biochemical and biophysical research …, 2013 - Elsevier
Sirtuins are NAD+-dependent deacetylases that regulate numerous cellular processes
including aging, DNA repair, cell cycle, metabolism, and survival under stress conditions …
including aging, DNA repair, cell cycle, metabolism, and survival under stress conditions …
Salermide up‐regulates death receptor 5 expression through the ATF4‐ATF3‐CHOP axis and leads to apoptosis in human cancer cells
G Liu, L Su, X Hao, N Zhong, D Zhong… - Journal of cellular …, 2012 - Wiley Online Library
Sirtuins (a class III histone deacetylase) have emerged as novel targets for cancer therapy.
Salermide, a reverse amide compound that inhibits Sirtuin 1 (Sirt1) and Sirtuin 2 (Sirt2), has …
Salermide, a reverse amide compound that inhibits Sirtuin 1 (Sirt1) and Sirtuin 2 (Sirt2), has …