Background Alveolar overdistension and repetitive derecruitment-recruitment contribute to
ventilator-induced lung injury (VILI). The authors investigated (1) whether inflammatory cell …

PURPOSE: Ventilator-induced lung injury (VILI) is a recognized complication of mechanical
ventilation. Although the specific mechanism by which mechanical ventilation causes lung …

The clinical relevance of experimental ventilator-induced lung injury (VILI)(1) has recently
received a resounding illustration by the Acute Respiratory Distress Syndrome (ARDS) …

Background The time course and mechanisms of resolution and repair, and the potential for
fibrosis following ventilation-induced lung injury (VILI), are unclear. We sought to examine …

IN this issue of ANESTHESIOLOGY, Whitehead et al. 1 bring experimental evidence
suggesting that a high tidal volume ventilation can markedly reduce the release of …

To understand ventilator-induced lung injury (VILI) during positive pressure ventilation,
mechanisms of normal alveolar mechanics must first be established. Isotropic “balloonlike” …

How ventilation strategy, specific mechanisms of mechanotransduction, and their individual
threshold values impact on VALI remains to be elucidated. In addition, clinical studies are …

Background The ventilator works mechanically on the lung parenchyma. The authors set out
to obtain the proof of concept that ventilator-induced lung injury (VILI) depends on the …

Understanding how the mechanisms of ventilator-induced lung injury (VILI), namely
atelectrauma and volutrauma, contribute to the failure of the blood-gas barrier and …

Mechanical ventilation is an essential method of patient support, but it may induce lung
damage, leading to ventilator-induced lung injury (VILI). VILI is the result of a complex …