Thousands of long noncoding RNAs (lncRNAs) have been annotated in eukaryotic
genomes, but comparative transcriptomic approaches are necessary to understand their …

The nucleus is a highly organized and dynamic environment where regulation and
coordination of processes such as gene expression and DNA replication are paramount. In …

Abstract Background Long non-coding RNAs (lncRNAs) have been implicated in diverse
biological processes. In contrast to extensive genomic annotation of lncRNA transcripts, far …

Background The role of long non-coding RNAs (lncRNAs) in controlling gene expression
has garnered increased interest in recent years. Sequencing projects, such as Fantom3 for …

Background Long considered to be the building block of life, it is now apparent that protein is
only one of many functional products generated by the eukaryotic genome. Indeed, more of …

Thousands of long noncoding RNAs (lncRNAs) have been discovered, but their functional
characterization has been slowed by a limited set of research tools. Here we review …

Although many long noncoding RNAs (lncRNAs) have been identified in human and other
mammalian genomes, there has been limited systematic functional characterization of these …

Long noncoding RNA (lncRNA) is a pivotal factor regulating various aspects of genome
activity. Genome regulation via DNA methylation and post-translational histone …

A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential,
are transcribed from the mammalian genome. They are emerging as important regulators in …

Over the past decade, the focus of molecular biology has shifted from being predominately
DNA and protein-centric to having a greater appreciation of RNA. It is now accepted that the …