CD4+ T cells are critical components of the adaptive immune system. The T cell receptor
(TCR) and co-receptor signaling cascades shape the phenotype and functions of CD4+ T …

Integrin adhesion receptors are critical for antigen recognition by T cells and for regulated
recirculation and trafficking into and through various tissues in the body. T‐cell receptor …

Lymphocytes integrate Ag and cytokine receptor signals to make cell fate decisions. Using a
specific reporter of TCR signaling that is insensitive to cytokine signaling, Nur77-eGFP, we …

The T cell antigen receptor (TCR) and pre-TCR complexes are composed of multiple signal-
transducing subunits (CD3γ, CD3δ, CD3ε, and ζ) that each contain one or more copies of a …

ABSTRACT T cell activation is brought about by recognition of peptide/MHC complexes on
an antigen-presenting cell (APC) by the T cell receptor (TCR). However, in general this …

While much is known about intracellular signaling events in T cells when T cell receptors
(TCRs) are engaged, the mechanism by which signaling is initiated is unclear. We have …

During the past several years, the critical role of costimulatory molecules in regulating T cell
responses has been demonstrated. Costimulatory molecule CD28 enhances whereas CTLA …

Part 1 of this review will highlight the basic components and signaling pathways by which
the T-cell antigen receptor (TCR) activates mature extrathymic T cells. TCR signaling …

The central requirement for the T cells of the immune system is the expression of cell surface
receptors capable of distinguishing between self and foreign antigens. These recognition …

Regulation of T cell activation requires two signals. First, appropriately presented Ag in the
context of MHC interacts with the T cell Ag receptor-CD3 complex. The best-studied second …