In the periphery, upon antigen recognition by αβTCR, naïve CD4 T cells undergo functional
differentiation and acquire the ability to produce a specific set of cytokines. At least four Th …

Regulation of T cell activation requires two signals. First, appropriately presented Ag in the
context of MHC interacts with the T cell Ag receptor-CD3 complex. The best-studied second …

Twenty years of investigation have yielded a detailed view of the signalling machinery
engaged by T-cell receptors (TCRs). Many of the fundamental insights into TCR signalling …

The T cell receptor (TCR) is a versatile receptor able to generate different signals that result
in distinct T cell responses. The pattern of early signals is determined by the TCR binding …

Downregulation of the TCR complex is believed to be intimately tied to T cell activation,
allowing serial triggering of receptors and desensitization of stimulated cells. We studied …

T cell receptors (TCRs) are protein complexes formed by six different polypeptides. In most T
cells, TCRs are composed of αβ subunits displaying immunoglobulin-like variable domains …

TCR down-regulation plays an important role in modulating T cell responses both during T
cell development and in mature T cells. Down-regulation of the TCR is induced by …

The essential function of the T cell receptor (TCR) is to translate the engagement of peptides
on the major histocompatibility complex (pMHC) into appropriate intracellular signals …

Engagement of antigen-specific T cell receptors (TCRs) is a prerequisite for T cell activation.
Acquisition of appropriate effector T cell function requires the participation of multiple signals …

The number of possible T cell activation outcomes resulting from T cell receptor (TCR)
engagement suggests that the TCR is able to differentially activate a myriad of signaling …