Determining how receptor ligand quality and quantity together control the biologic
responses of T cells is central to understanding normal and pathologic T cell immunity. Here …

Current models suggest that T cells that receive only signal-1 through antigenic stimulation
of the T cell receptor (TCR) become anergic, but will mount an immune response when a …

Primary T cell proliferative responses to TCR ligation plus CD28 costimulation are
surprisingly heterogeneous. Many cells that enter G1 fail to progress further through the cell …

The T-cell coreceptors CD4 and CD8 have well-characterized and essential roles in thymic
development, but how they contribute to immune responses in the periphery is unclear …

T cell receptor (TCR) recognition of peptide–major histocompatibility complex antigens can
elicit a diverse array of effector activities. Here we simultaneously analyze TCR engagement …

T cell receptor (TCR) antigen recognition induces the formation of a specialized
'immunological synapse'at the T cell: antigen presenting cell (APC) junction. This junction is …

The mechanism and stimulatory requirements of regulatory T cell (Treg)-mediated
suppression are still unclear. To assess the requirement for Treg stimulation by cognate …

T-cell activation by foreign antigen induces antigen specific T-cell clonal expansion and
differentiation and this response is regulated by signal transduction pathways initiated by …

Studies of T cell responses to altered peptide ligands (APLs) have provided functional
evidence that a T cell receptor (TCR) can interpret subtle changes in its ligand, resulting in …

The Perspective by J. Allison and M. Krummel discusses a paper in this issue of Science by
Waterhouse et al.(p. 985), which reports the lymphoproliferative phenotype of mice lacking …