The inflammasome is a multiprotein complex that mediates the activation of caspase-1,
which promotes secretion of the proinflammatory cytokines interleukin 1β (IL-1β) and IL-18 …

Background Mechanical ventilation (MV) is frequently used but can aggravate or cause lung
injury, known as ventilator-induced lung injury (VILI). However, the mechanisms are unclear …

The inflammasome pathway functions to regulate caspase‐1 activation in response to a
broad range of stimuli. Caspase‐1 activation is required for the maturation of the pivotal pro …

Nod-Like Receptor (NLR) is the largest family of Pathogen Recognition Receptors (PRRs)
that patrols the cytosolic environment. NLR engagement drives caspase-1 activation that …

Inflammasomes are multimeric protein complexes that initiate inflammatory cascades. Their
activation is a hallmark of many infectious or inflammatory diseases. Their composition and …

Inflammasomes are innate immune sensors that regulate caspase-1 mediated inflammation
in response to environmental, host-and pathogen-derived factors. The NLRP3 …

Infection with Listeria monocytogenes can cause meningitis and septicemia in newborn,
elderly, or immunocompromised individuals. Pregnant women are particularly susceptible to …

Inflammasomes are multiprotein complexes that include members of the NLR (nucleotide-
binding domain leucine-rich repeat containing) family and caspase-1. Once bacterial …

The NLRP3 inflammasome is an important component of the innate immune system.
However, its mechanism of activation remains largely unknown. We show that NLRP3 …

Endothelial dysfunction is responsible for multiple organ failure and the high mortality rate of
sepsis. Nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome plays an …