The inflammasomes induce maturation of pro-interleukin-1β (IL-1β) and pro-IL-18. We
investigated roles of the NLRP3 inflammasome in the pathogenesis of ulcerative colitis (UC) …

Inflammasomes are specialized inflammatory signaling platforms that govern the maturation
and secretion of proinflammatory cytokines, such as IL-1β and IL-18, through the regulation …

It is well known that the innate immune system can induce and regulate the development of
adaptive immunity. The NLRP3 inflammasome is a multiprotein complex that controls the …

Decreased expression of the Nlrp3 protein is associated with susceptibility to Crohn's
disease. However, the role of Nlrp3 in colitis has not been characterized. Nlrp3 interacts with …

Biochemical studies suggest that the NAIP family of NLR proteins are cytosolic innate
receptors that directly recognize bacterial ligands and trigger NLRC4 inflammasome …

Acute lung injury and acute respiratory distress syndrome (ALI/ARDS) is characterized by
uncontrolled progressive lung inflammation. Macrophages serve a key role in the …

Inflammation is a part of the body's immune response for protection against pathogenic
infections and other cellular damages; however, chronic inflammation is a major cause of …

Dying cells are capable of activating the innate immune system and inducing a sterile
inflammatory response. Here, we show that necrotic cells are sensed by the Nlrp3 …

NLRP6 is a member of the NLR (nucleotide-oligomerization domain-like receptor) family of
proteins that recognize pathogen-derived factors and damage-associated molecular …

Abstract Angiotensin II (Ang-II) is a widely studied hypertensive, profibrotic, and pro-
inflammatory peptide. In the heart, cardiac fibroblasts (CF) express type 1 angiotensin II …