Large molecular complexes known as inflammasomes regulate the release of IL-1β from
immune cells in response to infection and injury. Salmonella typhimurium infection is …

Objective and design We studied the involvement of calcium and calcium-activated NADPH
oxidases in NLRP3 inflammasome activation and IL-1β release to better understand …

The inflammasome is an emerging new pathway in innate immune defense against
microbial infection or endogenous danger signals. The inflammasome stimulates activation …

Cytoplasmic innate immune receptors are important therapeutic targets for diseases
associated with overproduction of proinflammatory cytokines. One cytoplasmic receptor …

Inflammasomes are a class of cytosolic protein complexes. They act as cytosolic innate
immune signal receptors to sense pathogens and initiate inflammatory responses under …

NLRP3 inflammasome is a critical player in innate immunity. Neutrophil recruitment to
tissues and effective neutrophil function are critical innate immune mechanisms for bacterial …

The NLRP3 inflammasome is a critical component of innate immunity that defends the host
from microbial infections. However, its aberrant activation contributes to the pathogenesis of …

Abstract The Gram-negative pathogen Campylobacter jejuni is the most common cause of
bacterial foodborne disease worldwide. The mechanisms that lead to bacterial invasion of …

IL‐1β is produced from inactive pro‐IL‐1β by activation of caspase‐1 brought about by a
multi‐subunit protein platform called the inflammasome. Many bacteria can trigger …

The Nod-like receptor protein 3 (NLRP3) inflammasome is a multi-protein complex
composed of NLRP3, pro-caspase-1, and apoptosis-associated speck-like protein that …