Microsatellite Stable Colorectal Cancers Stratified by the BRAF V600E Mutation Show Distinct Patterns of Chromosomal Instability

CE Bond, DJ Nancarrow, LF Wockner, L Wallace… - PLoS …, 2014 - journals.plos.org
The BRAF (V600E) mutation in colorectal cancers that are microsatellite stable (MSS)
confers a poor patient prognosis, whereas BRAF mutant microsatellite-unstable (MSI) …

Chromosomal Instability in BRAF Mutant, Microsatellite Stable Colorectal Cancers

CE Bond, A Umapathy, RL Buttenshaw, L Wockner… - 2012 - journals.plos.org
The BRAF oncogene is mutated in 15% of sporadic colorectal cancers. Approximately half of
these BRAF mutant cancers demonstrate frequent frameshift mutations termed microsatellite …

Prognostic value of BRAF and KRAS mutation status in stage II and III microsatellite instable colon cancers

EMV De Cuba, P Snaebjornsson… - … journal of cancer, 2016 - Wiley Online Library
Microsatellite instability (MSI) has been associated with favourable survival in early stage
colorectal cancer (CRC) compared to microsatellite stable (MSS) CRC. The BRAF V600E …

Microsatellite Instability and BRAF Mutation Testing in Colorectal Cancer Prognostication

P Lochhead, A Kuchiba, Y Imamura… - Journal of the …, 2013 - academic.oup.com
BRAF mutation in colorectal cancer is associated with microsatellite instability (MSI) through
its relationship with high-level CpG island methylator phenotype (CIMP) and MLH1 promoter …

Prognostic value of the combination of microsatellite instability and BRAF mutation in colorectal cancer

Y Yang, D Wang, L Jin, G Wu, Z Bai… - Cancer Management …, 2018 - Taylor & Francis
Purpose The aim of this study was to investigate the prognostic value of the combination of
microsatellite instability (MSI) and BRAF V600E mutation in colorectal cancer (CRC) …

Combination of microsatellite instability and BRAF mutation status for subtyping colorectal cancer

TT Seppälä, JP Böhm, M Friman, L Lahtinen… - British journal of …, 2015 - nature.com
Background: The objective of the study was to examine the role of microsatellite instability
(MSI) and BRAF V600E mutation in colorectal cancer (CRC) by categorising patients into …

The association between mutations in BRAF and colorectal cancer–specific survival depends on microsatellite status and tumor stage

H Bläker, E Alwers, A Arnold, E Herpel… - Clinical …, 2019 - Elsevier
Background & Aims Colorectal tumors with mutations in BRAF and microsatellite stability
(MSS) have been associated with adverse outcomes of patients. Combined tests for …

Prognostic impact of BRAF V600E mutation in patients with non-metastatic colorectal cancer with microsatellite instability: A systematic review and meta-analysis.

S Manthravadi, W Sun, A Saeed - 2018 - ascopubs.org
3597 Background: Colorectal cancer (CRC) displaying high levels of microsatellite instability
(MSI-H) has been associated with improved survival in colorectal cancer. MSI-H CRC is also …

MSI status is associated with distinct clinicopathological features in BRAF mutation colorectal cancer: A systematic review and meta-analysis

M Wu, YS Kim, HS Ryu, SC Choi, KY Kim… - … -Research and Practice, 2020 - Elsevier
Abstract Background Microsatellite stable (MSS) BRAF p. V600E mutation colorectal cancer
(BRAF-CRC) has a poor prognosis, whereas microsatellite instability (MSI) in BRAF-CRC is …

BRAF-mutated microsatellite stable colorectal carcinoma: an aggressive adenocarcinoma with reduced CDX2 and increased cytokeratin 7 immunohistochemical …

MS Landau, SF Kuan, S Chiosea, RK Pai - Human pathology, 2014 - Elsevier
Reduced CDX2 and cytokeratin 20 (CK20) expression in colorectal carcinoma with BRAF
mutation and high-level microsatellite instability (MSI-H) has been well documented. The …