Breast cancer is the most common cancer among women in the United States, with up to
30% of those diagnosed displaying a family history of breast cancer. To date, 18% of the …

More than 12% of women will be diagnosed with breast cancer in their lifetime. Although
there have been tremendous advances in elucidating genetic risk factors underlying both …

Importance To date, few studies have examined the extent to which polygenic single-
nucleotide variation (SNV)(formerly single-nucleotide polymorphism) scores modify risk for …

Genome-wide association studies (GWAS) and large-scale replication studies have
identified common variants in 79 loci associated with breast cancer, explaining∼ 14% of the …

PURPOSE This study assessed the joint association of pathogenic variants (PVs) in breast
cancer (BC) predisposition genes and polygenic risk scores (PRS) with BC in the general …

Genome-wide association studies have identified 72 loci associated with breast cancer
susceptibility. Seventeen of these are known to predispose to other cancers. High …

Linkage and candidate gene studies have identified several breast cancer susceptibility
genes, but the overall contribution of coding variation to breast cancer is unclear. To …

Genome-wide association studies (GWASs) have identified more than 150 common genetic
loci for breast cancer risk. However, the target genes and underlying mechanisms remain …

By combining data from 160,500 individuals with breast cancer and 226,196 controls of
Asian and European ancestry, we conducted genome-and transcriptome-wide association …

Breast cancer is the most commonly occurring invasive cancer among women and its
estimated incidence rate worldwide is approximately 1 million cases annually. Although …