The metabolic requirements of hematopoietic stem cells (HSCs) change with their cell cycle
activity. However, the underlying role of mitochondria remains ill-defined. Here we found …

The hematopoietic system produces new blood cells throughout life. Mature blood cells all
derived from a pool of rare long-lived hematopoietic stem cells (HSCs) that are mostly …

Haematopoietic stem cells (HSCs) differ from their committed progeny by relying primarily on
anaerobic glycolysis rather than mitochondrial oxidative phosphorylation for energy …

Quiescent and self‐renewing hematopoietic stem cells (HSCs) rely on glycolysis rather than
on mitochondrial oxidative phosphorylation (OxPHOS) for energy production. HSC reliance …

Regulated mechanisms of stem cell maintenance are key to preventing stem cell depletion
and aging. While mitochondrial morphology plays a fundamental role in tissue development …

Highlights•Specific modes of metabolism play important roles in hematopoietic stem cell
(HSC) self-renewal.•Heterogeneity and technical challenges have prevented the elucidation …

Cellular metabolism in hematopoietic stem cells (HSCs) is an area of intense research
interest, but the metabolic requirements of HSCs and their adaptations to their niches during …

Mesenchymal stem cells (MSCs) are pivotal to tissue homeostasis, repair, and regeneration
due to their potential for self-renewal, multilineage differentiation, and immune modulation …

Stem cells have the unique capacity to differentiate into many cell types during embryonic
development and postnatal growth. Through coordinated cellular behaviors (self‐renewal …

Somatic stem cells mediate tissue maintenance for the lifetime of an organism. Despite the
well-established longevity that is a prerequisite for such function, accumulating data argue …