Members of the catenin family were first isolated complexed with the cytoplasmic domains of
cadherins at cell-cell junctions, and this relationship is considered one of the defining …

Vertebrate beta-catenin plays a key role as a transducer of canonical-Wnt signals. We
earlier reported that, similar to beta-catenin, the cytoplasmic signaling pool of p120-catenin …

Abstract β-catenin is widely regarded as the primary transducer of canonical WNT signals to
the nucleus. In most vertebrates, there are eight additional catenins that are structurally …

The catenins are polypeptides that bind to the conserved cytoplasmic tail of cadherins and
are required for cad herin function. a-Catenin is related to vinculin and seems to be required …

Classical cadherins are cell-surface glycoproteins that mediate calcium-dependent cell
adhesion. The cytoplasmic domain of these glycoproteins is linked to the cytoskeleton …

For more than a decade, cell, developmental and cancer investigators have brought about a
wide interest in the biology of catenin proteins, an attraction being their varied functions …

The carboxyl terminus-truncated cadherin (nonfunctional cadherin) has no cell adhesion
activity probably because of its failure to associate with cytoplasmic proteins called alpha …

Cadherins are transmembrane receptors with an extracellular domain that participates in
homophilic cell to cell adhesion and a cytoplasmic domain that associates with proteins …

Publisher Summary This chapter examines the role of catenins in regulating membrane–
cytoskeleton interactions with cadherin cell adhesion proteins. The cadherins are members …

The Wnt-1 proto-oncogene induces the accumulation of β-catenin and plakoglobin, two
related proteins that associate with and functionally modulate the cadherin cell adhesion …