Abstract The International Mouse Phenotyping Consortium (IMPC) continues to expand the
catalogue of mammalian gene function by conducting genome and phenome-wide …

Nearly 10 years after the completion of the human genome project, and the report of a
complete sequence of the mouse genome, it is salutary to reflect that we remain remarkably …

The use of model organisms to provide information on gene function has proved to be a
powerful approach to our understanding of both human disease and fundamental …

We are entering a new era of mouse phenomics, driven by large-scale and economical
generation of mouse mutants coupled with increasingly sophisticated and comprehensive …

Abstract The International Mouse Phenotyping Consortium (IMPC) web portal (http://www.
mousephenotype. org) provides the biomedical community with a unified point of access to …

Abstract The International Mouse Phenotyping Consortium (IMPC; https://www.
mousephenotype. org/) web portal makes available curated, integrated and analysed …

New sequencing technologies have ushered in a new era for diagnosis and discovery of
new causative mutations for rare diseases. However, the sheer numbers of candidate …

Abstract Model organisms have played a huge part in the history of studies of human genetic
disease, both in identifying disease genes and characterizing their normal and abnormal …

Two large-scale phenotyping efforts, the European Mouse Disease Clinic (EUMODIC) and
the Wellcome Trust Sanger Institute Mouse Genetics Project (SANGER-MGP), started during …

The powerful and wide-ranging genetic tools available in the laboratory mouse make it the
major experimental model for studying mammalian gene function in vivo and modelling …