Benefit of clopidogrel over aspirin is amplified in patients with a history of ischemic events

PA Ringleb, DL Bhatt, AT Hirsch, EJ Topol, W Hacke - Stroke, 2004 - Am Heart Assoc
Background and Purpose—The goal of this study was to examine the influence of
preexisting symptomatic atherosclerotic disease on subsequent ischemic event rates and …

Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double …

HC Diener, J Bogousslavsky, LM Brass, C Cimminiello… - The Lancet, 2004 - thelancet.com
Background Clopidogrel was superior to aspirin in patients with previous manifestations of
atherothrombotic disease in the CAPRIE study and its benefit was amplified in some high …

Therapeutic benefit: aspirin revisited in light of the introduction of clopidogrel

PB Gorelick, GVR Born, RB D'Agostino, DF Hanley Jr… - Stroke, 1999 - Am Heart Assoc
Background—Antiplatelet agents are widely recognized for their efficacy in reducing the
occurrence of vascular events in patients with atherothrombotic disease. Aspirin is currently …

Management of atherothrombosis with clopidogrel in high-risk patients with recent transient ischaemic attack or ischaemic stroke (MATCH): study design and baseline …

HC Diener, J Bogousslavsky, LM Brass… - Cerebrovascular …, 2004 - karger.com
Background: The CAPRIE study showed the superiority of clopidogrel over acetylsalicylic
acid (ASA) for reducing the combined risk of major atherothrombotic events in patients with …

Clopidogrel and aspirin in acute ischemic stroke and high-risk TIA

SC Johnston, JD Easton, M Farrant… - … England Journal of …, 2018 - Mass Medical Soc
Background Combination antiplatelet therapy with clopidogrel and aspirin may reduce the
rate of recurrent stroke during the first 3 months after a minor ischemic stroke or transient …

Effect of clopidogrel plus ASA vs. ASA early after TIA and ischaemic stroke: a substudy of the CHARISMA trial

GJ Hankey, SC Johnston, JD Easton… - … Journal of Stroke, 2011 - journals.sagepub.com
Background The Clopidogrel for High Atherothrombotic Risk and Ischaemic Stabilisation,
Management and Avoidance (CHARISMA) trial reported no statistically significant benefit of …

Benefits and risks of clopidogrel vs. aspirin monotherapy after recent ischemic stroke: a systematic review and meta‐analysis

M Paciaroni, B Ince, B Hu, JS Jeng… - Cardiovascular …, 2019 - Wiley Online Library
Aim. Though combination of clopidogrel added to aspirin has been compared to aspirin
alone in patients with stroke or transient ischemic attack, limited data exists on the relative …

Recurrent ischemic lesions after acute atherothrombotic stroke: clopidogrel plus aspirin versus aspirin alone

KS Hong, SH Lee, EG Kim, KH Cho, DI Chang, JH Rha… - Stroke, 2016 - Am Heart Assoc
Background and Purpose—In patients with acute ischemic stroke caused by large artery
atherosclerosis, clopidogrel plus aspirin versus aspirin alone might be more effective to …

Clopidogrel with aspirin in acute minor stroke or transient ischemic attack (CHANCE) trial: one-year outcomes

Y Wang, Y Pan, X Zhao, H Li, D Wang, SC Johnston… - Circulation, 2015 - Am Heart Assoc
Background—The Clopidogrel in High-risk patients with Acute Non-disabling
Cerebrovascular Events (CHANCE) trial showed that the combined treatment of clopidogrel …

Rationale and design of a randomized, double-blind trial comparing the effects of a 3-month clopidogrel-aspirin regimen versus aspirin alone for the treatment of high …

Y Wang, SC Johnston, CHANCE investigators - American heart journal, 2010 - Elsevier
BACKGROUND: Acute nondisabling cerebrovascular events are common and often portend
a disabling stroke. Aspirin is the only antiplatelet agent to have been studied in patients …