Diesel exhaust particles induce CYP1A1 and pro-inflammatory responses via differential pathways in human bronchial epithelial cells

AI Totlandsdal, FR Cassee, P Schwarze… - Particle and fibre …, 2010 - Springer
Background Exposure to diesel engine exhaust particles (DEPs) has been associated with
several adverse health outcomes in which inflammation seems to play a key role. DEPs …

Oxidative stress, genotoxicity, and vascular cell adhesion molecule expression in cells exposed to particulate matter from combustion of conventional diesel and …

JG Hemmingsen, P Møller, JK Nøjgaard… - … science & technology, 2011 - ACS Publications
Our aim was to compare hazards of particles from combustion of biodiesel blends and
conventional diesel (D100) in old and improved engines. We determined DNA damage in …

Effects of diesel exposure on lung function and inflammation biomarkers from airway and peripheral blood of healthy volunteers in a chamber study

Y Xu, L Barregard, J Nielsen, A Gudmundsson… - Particle and fibre …, 2013 - Springer
Background Exposure to diesel exhaust causes inflammatory responses. Previous
controlled exposure studies at a concentration of 300 μg/m 3 of diesel exhaust particles …

Differential proinflammatory responses induced by diesel exhaust particles with contrasting PAH and metal content

AI Totlandsdal, M Låg, E Lilleaas… - Environmental …, 2015 - Wiley Online Library
Exposure to diesel engine exhaust particles (DEPs), representing a complex and variable
mixture of components, has been linked with cellular production and release of several …

Health effects of exposure to diesel exhaust in diesel-powered trains

MHG Andersen, M Frederiksen, AT Saber… - Particle and fibre …, 2019 - Springer
Background Short-term controlled exposure to diesel exhaust (DE) in chamber studies have
shown mixed results on lung and systemic effects. There is a paucity of studies on well …

Effect of diesel exhaust particulate (DEP) on immune responses: contributions of particulate versus organic soluble components

PD Siegel, RK Saxena, QB Saxena… - Journal of Toxicology …, 2004 - Taylor & Francis
The effect of diesel exhaust particulate (DEP) exposure on innate, cellular and humoral
pulmonary immunity was studied using high-dose, acute-exposure rat, mouse, and cell …

Biodiesel versus diesel exposure: enhanced pulmonary inflammation, oxidative stress, and differential morphological changes in the mouse lung

N Yanamala, MK Hatfield, MT Farcas… - Toxicology and applied …, 2013 - Elsevier
The use of biodiesel (BD) or its blends with petroleum diesel (D) is considered to be a viable
approach to reduce occupational and environmental exposures to particulate matter (PM) …

Nitric oxide and superoxide mediate diesel particle effects in cytokine-treated mice and murine lung epithelial cells—implications for susceptibility to traffic-related air …

ND Manzo, AJ LaGier, R Slade, AD Ledbetter… - Particle and fibre …, 2012 - Springer
Background Epidemiologic studies associate childhood exposure to traffic-related air
pollution with increased respiratory infections and asthmatic and allergic symptoms. The …

Biological effects of diesel exhaust particles (DEP). II. Acute toxicity of DEP introduced into lung by intratracheal instillation

T Ichinose, A Furuyama, M Sagai - Toxicology, 1995 - Elsevier
Histopathological examination and cytological analyses in bronchial alveolar lavage fluids
(BALF) were performed to clarify the acute toxicity of diesel exhaust particles (DEP) …

Prevalidation of in vitro continuous flow exposure systems as alternatives to in vivo inhalation safety evaluation experimentations: outcome from MAAPHRI-PCRD5 …

JP Morin, V Hasson, M Fall, E Papaioanou… - Experimental and …, 2008 - Elsevier
Diesel engine emission aerosol-induced toxicity patterns were compared using both in vitro
(organotypic cultures of lung tissue) and in vivo experimentations mimicking the inhalation …