Chronic myelogenous leukemia: update on biology and treatment.

S Faderl, HM Kantarjian, M Talpaz - Oncology (Williston Park, NY), 1999 - europepmc.org
Chronic myelogenous leukemia (CML) is a myeloproliferative disorder that follows a
characteristic clinical course in which a chronic phase of variable duration precedes an …

Chronic myelogenous leukemia: biology and therapy

S Faderl, M Talpaz, Z Estrov… - Annals of internal …, 1999 - acpjournals.org
Chronic myelogenous leukemia is a myeloproliferative disorder. It is characterized by a
biphasic or triphasic clinical course in which a benign chronic phase is followed by …

Chronic myeloid leukemia: pathophysiology, diagnostic parameters, and current treatment concepts

C Sillaber, M Mayerhofer, H Agis, V Sagaster… - Wiener Klinische …, 2003 - Springer
Chronic myeloid leukemia (CML) is a stem cell disease characterized by excessive
accumulation of clonal myeloid (precursor) cells in hematopoietic tissues. CML cells display …

Chronic myeloid leukemia: a perspective of the clinical and biologic issues of the chronic phase

RT Silver - Hematology/Oncology clinics of North America, 1990 - Elsevier
Although chronic myeloid leukemia is an incurable disease for the majority of patients,
striking advances in our understanding of cell biology, molecular genetics, and new …

Chronic myelogenous leukemia-past, present, and future

HM Kantarjian, M Talpaz… - Hematologic …, 1988 - mdanderson.elsevierpure.com
Recent advances in the understanding of the molecular biology underlying CML, and in its
therapy, have stimulated renewed interest in the entity. The early availability of oral single …

The biology of chronic myeloid leukemia

S Faderl, M Talpaz, Z Estrov, S O'Brien… - … England Journal of …, 1999 - Mass Medical Soc
Chronic myeloid leukemia (CML) is a clonal myeloproliferative expansion of transformed,
primitive hematopoietic progenitor cells. It involves myeloid, monocytic, erythroid …

Clonal evolution in chronic myelogenous leukemia

J Cortes, ME O'Dwyer - Hematology/Oncology Clinics, 2004 - hemonc.theclinics.com
Chronic myelogenous leukemia (CML) is a clonal hematopoietic stem cell disorder
characterized by a specific chromosomal translocation, t (9; 22), that results in a shortened …

[HTML][HTML] Chronic myeloid leukaemia in the 21st century

R Frazer, AE Irvine, MF McMullin - The Ulster medical journal, 2007 - ncbi.nlm.nih.gov
Chronic Myeloid Leukaemia (CML) is a clonal, myeloproliferative disease that develops
when a single, pluripotential, haemopoetic stem cell acquires the Philadelphia chromosome …

Chronic myeloid leukemia

CL Sawyers - New England Journal of Medicine, 1999 - Mass Medical Soc
In the past decade clinical and laboratory studies have led to important new insights into the
biology of chronic myeloid leukemia (CML). Basic science has defined the molecular …

Biology of chronic myelogenous leukemia

CM Verfaillie - Hematology/oncology clinics of North America, 1998 - Elsevier
Chronic myelogenous leukemia (CML) is a malignant disease of the human hematopoietic
stem cell. The disease is characterized by an abnormal expansion of granulocytic …