CRISPR/Cas9 editing of the genome for cancer modeling
A Guernet, L Grumolato - Methods, 2017 - Elsevier
The CRISPR/Cas9 revolution has democratized access to genome editing in many
biological fields, including cancer research. Cancer results from the multistep accumulation …
biological fields, including cancer research. Cancer results from the multistep accumulation …
[HTML][HTML] CRISPR-Cas9: a revolutionary tool for cancer modelling
R Torres-Ruiz, S Rodriguez-Perales - International Journal of Molecular …, 2015 - mdpi.com
The cancer-modelling field is now experiencing a conversion with the recent emergence of
the RNA-programmable CRISPR-Cas9 system, a flexible methodology to produce …
the RNA-programmable CRISPR-Cas9 system, a flexible methodology to produce …
Modeling cancer in the CRISPR era
In just a few short years, CRISPR/Cas9 genome editing has fundamentally changed basic,
agricultural, and biomedical research, but no field has felt a more profound impact than …
agricultural, and biomedical research, but no field has felt a more profound impact than …
[HTML][HTML] The use of CRISPR/Cas9-based gene editing strategies to explore cancer gene function in mice
L van der Weyden, J Jonkers, DJ Adams - Current Opinion in Genetics & …, 2021 - Elsevier
CRISPR/Cas9 systems have revolutionised the field of gene editing, allowing for precise
modifications to be generated in vivo to mimic the genetic events found in human cancer …
modifications to be generated in vivo to mimic the genetic events found in human cancer …
Applications of CRISPR-Cas9 Technology in Translational Research on solid-tumor cancers
P Chen, L You, Y Lu - The CRISPR Journal, 2018 - liebertpub.com
Since its introduction to genome editing, CRISPR-Cas9 has been used to generate cell and
animal models of disease, investigate relations between genomes and phenotypes, and …
animal models of disease, investigate relations between genomes and phenotypes, and …
Modeling cancer processes with CRISPR-Cas9
XJ Lu, X Qi, DH Zheng, LJ Ji - Trends in biotechnology, 2015 - cell.com
CRISPR-Cas9 is an RNA-guided site-specific DNA editing tool which, together with its
reprogrammed versions such as nickase Cas9 and dead Cas9, enables quick modeling of …
reprogrammed versions such as nickase Cas9 and dead Cas9, enables quick modeling of …
CRISPR-Cas9 causes chromosomal instability and rearrangements in cancer cell lines, detectable by cytogenetic methods
E Rayner, MA Durin, R Thomas, D Moralli… - The CRISPR …, 2019 - liebertpub.com
CRISPR-Cas9 has quickly become the method of choice for genome editing, with multiple
publications describing technical advances and novel applications. It has been widely …
publications describing technical advances and novel applications. It has been widely …
[HTML][HTML] Precision cancer mouse models through genome editing with CRISPR-Cas9
The cancer genome is highly complex, with hundreds of point mutations, translocations, and
chromosome gains and losses per tumor. To understand the effects of these alterations …
chromosome gains and losses per tumor. To understand the effects of these alterations …
[HTML][HTML] CRISPR/Cas9: transcending the reality of genome editing
S Chira, D Gulei, A Hajitou, AA Zimta… - … Therapy-Nucleic Acids, 2017 - cell.com
With the expansion of the microbiology field of research, a new genome editing tool arises
from the biology of bacteria that holds the promise of achieving precise modifications in the …
from the biology of bacteria that holds the promise of achieving precise modifications in the …
[HTML][HTML] CRISPR-Cas9: from genome editing to cancer research
Cancer development is a multistep process triggered by innate and acquired mutations,
which cause the functional abnormality and determine the initiation and progression of …
which cause the functional abnormality and determine the initiation and progression of …