Although the protein leak of early diabetic nephropathy is said to be purely a glomerular
lesion, there is still controversy as to the existence of a tubular component. We have …

Introduction Diabetic nephropathy becomes clinically apparent when after many years of
diabetes mellitus, proteinuria, hypertension and renal insufficiency develop [1]. Careful …

Dear Sir, We would like to make a few comments of a technical nature concerning the
statements in the letter by Dr. Simpson in the August 1982 issue [1]. When assessing …

The urinary excretion of two low-molecular-weight proteins (beta 2-microglobulin and retinol-
binding protein) was measured in 12 insulin-dependent diabetic patients with persistent …

To evaluate the importance of tubular proteinuria in diabetic nephropathy, we studied the
serial changes of micro-albuminuria, microproteinuria and protein patterns by sodium …

Abstract Aims/Hypothesis: Streptozotocin (STZ) diabetic rats are characterized by the
development of albuminuria. It is not known, however, whether the excess excretion of …

In diabetes mellitus a breakdown of the glomerular capillary-blood barrier with the
development of proteinuria (Albustix positive) is usually accepted as marking the onset of …

A longitudinal study evaluating the time course of the transition from normal to micro‐
albuminuria, and then on to macroalbuminuria, was made over a mean period of 7 years in …

Summary Approximately 40–45% of insulin-dependent diabetic (IDD) patients will develop,
with time, clinical proteinuria, a forerunner of certain renal failure. Before this, however, up to …

Small amounts of urinary proteins observed at early stages of diabetic nephropathy may
result from both glomerular and proximal tubular dysfunction. However, the relative …