Recent advances in genome editing technologies have magnified the prospect of single-
dose cures for many genetic diseases. For most genetic disorders, precise DNA correction is …

ABSTRACT RNA editing by cytosine and adenosine deaminases changes the identity of the
edited bases. While cytosines are converted to uracils, adenines are converted to inosines. If …

Clinical Genome Editing Therapeutic editing of the human genome has long been a holy
grail of genetic medicine. Different approaches are founded on a bedrock of basic laboratory …

Precise and efficient use of genome editing tools are hampered by the introduction of DNA
double-strand breaks, donor DNA templates, or homology-directed repair. A recent study …

The ability to manipulate the genome with precise spatial and nucleotide resolution
(genome editing) has been a powerful research tool. In the past decade, the tools and …

Genome editing is the process of precisely modifying the nucleotide sequence of the
genome. It has provided a powerful approach to research questions but, with the …

Nuclease-based genome editing strategies hold great promise for the treatment of blood
disorders. However, a major drawback of these approaches is the generation of potentially …

Targeted point mutagenesis through homologous recombination has been widely used in
genetic studies and holds considerable promise for repairing disease-causing mutations in …

Adenine base editors (ABEs) enable precise and efficient conversion of target A• T base
pairs to G• C base pairs in genomic DNA with a minimum of by-products. While ABEs have …

We describe base editors that combine both cytosine and adenine base-editing functions. A
codon-optimized fusion of the cytosine deaminase PmCDA1, the adenosine deaminase …