Lipoxygenases (LOX) are enzymes that catalyze polyunsaturated fatty acid peroxidation and
have a non-heme iron atom located in their active site. They are implicated in the …

Lipoxygenases (LOXs), key enzymes involved in the biosynthesis of leukotrienes, are well
known to participate in the inflammatory and immune responses. With the recent reports of …

Inflammation is caused by a cascade of events, one of which is the metabolism of
arachidonic acid, that begins with oxidation by the enzyme 5-lipoxygenase. 5-Lipoxygenase …

The lipoxygenases (LOX) are a family of non-heme iron-containing dioxygenases which
catalyze the stereospecific insertion of molecular oxygen into arachidonic acid, leading to …

Inhibition of leukotriene biosynthesis is considered to be one of the potential treatment
strategies for controlling inflammation, respiratory diseases and many neurodegenerative …

Lipoxygenase (5-LO) is one of the key enzymes involved in the production of pro-
inflammatory mediators, such as leukotriene B4 and cysteinyl leukotrienes. Inhibition of 5-LO …

The inhibitors of 5-LOX control the overproduction of pro-inflammatory mediators known as
leukotrienes (LTs) and thus have therapeutic relevance in the treatment of various diseases …

Inflammation is a self-protective response to start the healing process. An anti-inflammatory
target worth developing are lipoxygenase inhibitors, which have been studied for several …

Flavones are a group of about 4000 naturally occurring compounds that are ubiquitous in
many plants and important constituents of the human diet. They have been recognized to …

Hydroxytyrosol is one of the most important phytochemical constituents of olive oil and
possesses a very interesting pharmacological profile ranging from antioxidant, antimicrobial …