Accurate subclassification of leukemia and the identification of prognostic determinants are
essential to guide therapy and to improve patients' outcome. According to present standards …

The standard methods to diagnose leukemia are cytomorphology and, in some cases,
histology, which both are supplemented by cytochemistry and multiparameter …

Purpose The Microarray Innovations in Leukemia study assessed the clinical utility of gene
expression profiling as a single test to subtype leukemias into conventional categories of …

Over the last decades, significant advances have been made in the knowledge and
treatment of acute myeloid leukemia (AML). The WHO has recognized this new information …

Background In patients with acute myeloid leukemia (AML) a combination of methods must
be used to classify the disease, make therapeutic decisions, and determine the prognosis …

Acute myeloid leukemia (AML) is the most common and severe form of acute leukemia
diagnosed in adults. Owing to its heterogeneity, AML is divided into classes associated with …

Over the past two decades, hematologic malignancies have been extensively evaluated due
to the introduction of powerful technologies, such as conventional karyotyping, FISH …

Background In patients with acute myeloid leukemia (AML), the presence or absence of
recurrent cytogenetic aberrations is used to identify the appropriate therapy. However, the …

BACKGROUND AND OBJECTIVES: Microarray gene expression profiling has been widely
applied to characterize hematologic malignancies, has attributed a molecular signature to …

Purpose To identify novel genomic regions of interest in acute myeloid leukemia (AML) with
complex karyotypes, we applied comparative genomic hybridization to microarrays (array …