Ionizing radiation‐induced death in bovine lens epithelial cells: Mechanisms and influence of irradiation dose rate

Y Belkacémi, G Piel, P Rat, F Julia… - … journal of cancer, 2000 - Wiley Online Library
We recently reported, in a series of patients receiving total body irradiation before transplant,
an influence of dose rate (DR) on cataract formation. The aim of our present in vitro study …

Dotting the eyes: mouse strain dependency of the lens epithelium to low dose radiation-induced DNA damage

SGR Barnard, J Moquet, S Lloyd… - … Journal of Radiation …, 2018 - Taylor & Francis
Purpose: Epidemiological evidence regarding the radiosensitivity of the lens of the eye and
radiation cataract development has led to changes in the EU Basic Safety Standards for …

[HTML][HTML] Lifetime study in mice after acute low-dose ionizing radiation: a multifactorial study with special focus on cataract risk

C Dalke, F Neff, SK Bains, S Bright, D Lord… - Radiation and …, 2018 - Springer
Because of the increasing application of ionizing radiation in medicine, quantitative data on
effects of low-dose radiation are needed to optimize radiation protection, particularly with …

Early responses to low-dose ionizing radiation in cellular lens epithelial models

M Ahmadi, S Barnard, E Ainsbury… - Radiation …, 2022 - meridian.allenpress.com
Cataract is the leading cause of visual impairment which can result in blindness. Cataract
formation has been associated with radiation exposure; however, the mechanistic …

Radiation effects on late cytopathological parameters in the murine lens relative to particle fluence

F Tao, P Powers-Risius, EL Alpen… - Advances in Space …, 1994 - Elsevier
Lenses of mice irradiated with 250 MeV protons, 670 MeV/amu 20 Ne, 600 MeV/amu 56 Fe,
600 MeV/amu 93 Nb and 593 MeV/amu 139 La ions were evaluated by analyzing …

[HTML][HTML] DNA damage in lens epithelial cells exposed to occupationally-relevant X-ray doses and role in cataract formation

I Udroiu, A Sgura, A Chendi, L Lasagni, M Bertolini… - Scientific Reports, 2020 - nature.com
The current framework of radiological protection of occupational exposed medical workers
reduced the eye-lens equivalent dose limit from 150 to 20 mSv per year requiring an …

Radiation-induced lens opacity and cataractogenesis: A lifetime study using mice of varying genetic backgrounds

RA McCarron, SGR Barnard, G Babini… - Radiation …, 2022 - meridian.allenpress.com
Recent epidemiological findings and reanalysis of historical data suggest lens opacities
resulting from ionizing radiation exposures are likely induced at lower doses than previously …

Radiation cataract and mitosis

BV Worgul, H Rothstein - Ophthalmic Research, 1975 - karger.com
X-irradiation of frog eyes with natural and experimentally induced differences in lenticular
mitotic activity reveals cataractogenesis to be dependent on the proliferative activity of the …

In vitro exposure of human lens epithelial cells to X-rays at varied dose-rates leads to protein-level changes relevant to cataractogenesis

V Chauhan, NQ Vuong, S Bahia… - … Journal of Radiation …, 2021 - Taylor & Francis
Background Accumulated body of evidence shows that ionizing radiation increases the risk
of cataracts. The mechanisms are not clear and the International Commission on …

Lens epithelial cell apoptosis is an early event in the development of UVB-induced cataract

WC Li, A Spector - Free Radical Biology and Medicine, 1996 - Elsevier
Epidemiological and experimental studies have revealed that exposure to UV can induce
cataractogenesis. To investigate the mechanism of this induction, viability of the lens …