Background Uveal melanoma (UM), the most prevalent intraocular tumor in adults, is a
highly metastatic and drug resistant lesion. Recent studies have demonstrated cytotoxic and …

Background Mifepristone (MF) has been largely used in reproductive medicine due to its
capacity to modulate the progesterone receptor (PR). The study of MF has been expanded …

Background The prototypical antiprogestin mifepristone exhibits potent growth inhibition
activity towards ovarian cancer cells in vitro and in vivo. The aim of this research was to …

Purpose: These studies were designed to determine whether the synthetic steroid
mifepristone inhibits ovarian cancer growth in vitro and in vivo and the molecular …

Repopulation of cancer cells escaping lethal chemotherapy is a critical factor hindering
treatment success. One strategy to inhibit tumor cell repopulation is the use of cytostatic …

Rationale: To provide evidence to support the provocative statement that the progesterone
receptor modulator (antagonist) mifepristone may be the best single anticancer drug to use …

Background Advanced ovarian cancer is treated with cytoreductive surgery and combination
platinum-and taxane-based chemotherapy. Although most patients have acute clinical …

Background Previous work in our laboratory demonstrated that antiprogestin mifepristone
impairs the growth and adhesion of highly metastatic cancer cells, and causes changes in …

We have previously shown that the antiprogestin and antiglucocorticoid mifepristone inhibits
the growth of ovarian cancer cells. In this work, we hypothesized that cellular stress caused …

The pharmacology of progestins includes actions initiated by various cellular targets,
including classic receptors characterized as nuclear transcription factors (nPR), G-protein …