Pancreatic cancer has a poor prognosis. It is reported that the PI3K/Akt pathway is activated
in many cancers, and inhibition of the PI3K/Akt pathway can induce cell apoptosis in most …

AIM: Polo-like kinase 1 (PLK1) serine/threonine kinase plays a vital role in multiple phases
of mitosis in gastric cancer cells. To investigate the effect of PLK1 depletion on mitosis and …

Polo‐like kinase 1 (PLK1), one of serine/threonine‐protein kinase, has been demonstrated
to play pivotal roles in malignant transformation. Here we illustrated the clinicopathological …

BI2536 is a highly selective and potent inhibitor of polo-like kinase 1 (PLK1). In this study,
we aimed to determine whether BI2536 and cisplatin can synergistically inhibit the …

OBJECTIVE: Polo like kinase 1 (PLK1), an oncogene, is a ubiquitously expressed
serine/threonine protein kinase. We aimed at investigating the role of PLK1 in glioma …

Background: There is abundant evidence from in vivo and in vitro studies thatPolo-like
kinase 1 (PLK1) plays a crucial role in the regulation of proliferative activity of normal and …

Pancreas cancer is the fourth leading cause of cancer-related death in adults in the United
States. New molecular targets for diagnosis and therapy of this disease are desperately …

Pancreatic cancer has a particularly poor prognosis compared to other tumors. The peculiar
hyperinsulin microenvironment of the pancreas is formed due to the endocrine secretion of …

Aims Polo-like kinase 2 (PLK2) belongs to a family of serine/threonine kinases, and it is
involved in tumorigenesis. The present study aimed to explore the potential clinical …

Polo‐like kinase 1 (PLK1) is centrally involved in the regulation of mitosis in normal and
malignant cells. It is known that inhibition of PLK1 expression in vitro and in vivo leads to …