Formulation and optimization of lacidipine loaded niosomal gel for transdermal delivery: in-vitro characterization and in-vivo activity

M Qumbar, SS Imam, J Ali, J Ahmad, A Ali - Biomedicine & …, 2017 - Elsevier
The aim of the present research work is to formulate lacidipine (LAC) loaded niosomes
formulation for the management of hypertension by thin film hydration technique. The …

Novel non-ionic surfactant proniosomes for transdermal delivery of lacidipine: optimization using 23 factorial design and in vivo evaluation in rabbits

SM Soliman, NS Abdelmalak, ON El-Gazayerly… - Drug …, 2016 - Taylor & Francis
Context: Proniosomes offer a versatile vesicle drug delivery concept with potential for
delivery of drugs via transdermal route. Objectives: To develop proniosomal gel using …

A novel transdermal nanoethosomal gel of lercanidipine HCl for treatment of hypertension: optimization using Box-Benkhen design, in vitro and in vivo …

HF Salem, SF El-Menshawe, RA Khallaf… - Drug delivery and …, 2020 - Springer
Poor bioavailability of drugs via oral route is the greatest challenge facing drug formulation.
To overcome this obstacle, transdermal route was commonly used as an alternative route to …

Formulation of niosomal gel for enhanced transdermal lopinavir delivery and its comparative evaluation with ethosomal gel

KK Patel, P Kumar, HP Thakkar - AAPS pharmscitech, 2012 - Springer
The aim was to develop niosomal gel as a transdermal nanocarrier for improved systemic
availability of lopinavir. Niosomes were prepared using thin-film hydration method and …

Investigating superiority of novel bilosomes over niosomes in the transdermal delivery of diacerein: in vitro characterization, ex vivo permeation and in vivo skin …

DE Aziz, AA Abdelbary, AI Elassasy - Journal of liposome research, 2019 - Taylor & Francis
Skin is considered the most accessible organ of the body because of its underlying capillary
network. However, stratum corneum (SC), the upper most layer of skin, represents major …

Diacerein niosomal gel for topical delivery: development, in vitro and in vivo assessment

KM El-Say, FI Abd-Allah, AE Lila… - Journal of liposome …, 2016 - Taylor & Francis
The purpose of this study was to load diacerein (DCR) in niosomes by applying response
surface methodology and incorporate these niosomes in gel base for topical delivery. Box …

[PDF][PDF] Evaluation of different compositions of niosomes to optimize aceclofenac transdermal delivery

AB Solanki, JR Parikh, RH Parikh… - Asian journal of …, 2010 - academia.edu
Purpose: To optimize the composition of niosomes containing aceclofenac for transdermal
application, with a view to improve permeation of drug during an extended period of time …

Innovative topical niosomal gel formulation containing diclofenac sodium (niofenac)

J Akbari, M Saeedi, K Morteza-Semnani… - Journal of Drug …, 2022 - Taylor & Francis
The purpose of this research was to enhance the transdermal delivery of diclofenac sodium
niosomal formulations. To characterise the obtained niosomes, SEM, XRPD, DSC and ATR …

Investigating the potential of utilizing glycerosomes as a novel vesicular platform for enhancing intranasal delivery of lacidipine

MJ Naguib, S Salah, SAA Halim… - International Journal of …, 2020 - Elsevier
Lacidipine is a potent dihydropyridine calcium channel blocker used for management of
hypertension and atherosclerosis. The drug has low and fluctuating oral bioavailability …

A novel vesicular transdermal delivery of nifedipine – preparation, characterization and in vitro/in-vivo evaluation

VR Yasam, SL Jakki, J Natarajan, S Venkatachalam… - Drug …, 2016 - Taylor & Francis
Nifedipine is a calcium channel blocker extensively used in the treatment of anginal and
hypertension. On oral administration it undergoes extensive first pass metabolism, which …