Bryodin 1 (BD1) is a potent ribosome-inactivating protein (RIP) isolated from the plant
Bryonia dioica. It is relatively nontoxic in rodents (LD50> 40 mg/kg) and represents a …

Two ribosome-inactivating proteins (RIPs) were isolated and characterized from the roots of
Bryonia dioica. One of these was a novel 27-kDa protein termed bryodin 2 (BD2), while the …

The major limitation to the use of immunotoxins in the clinic is the toxicity associated with the
toxin moiety. BD1-G28-5 single-chain Fv (sFv) is a single-chain immunotoxin targeted to …

Bryonia dioica (Cucurbitaceae family) produces at least two type I ribosome-inactivating
proteins, bryodin 1 (BD1) and bryodin 2 (BD2). A cDNA sequence encoding BD1 was …

The molecular cloning and expression of biologically active ribosome-inactivating protein
bryodin 1 are described. A complete amino acid and oligonucleotide Sequence encod ing …

A protein, here named trichokirin, was extracted from the seeds of Trichosanthes kirilowii
and purified by ion‐exchange and gel‐filtration chromatography. Trichokirin is a basic …

The aim of this study was to determine the suitability of a ribosome-inactivating protein (RIP)
from barley endosperm for use as an immunotoxin. This barley RIP is identical with the 30 …

Background Immunotherapy is fast emerging as one of the leading modes of treatment of
cancer, in combination with chemotherapy and radiation. Use of immunotoxins, proteins …

Proteins 1 that catalytically inactivate eukaryotic ribosomes have been identified in the
extracts of a wide variety of plants [1–3]. Such ribosome-inactivating proteins can be divided …

Plant ribosome-inactivating proteins (RIPs) are RNA N-glycosidases that inhibit protein
synthesis in cells. Abrin, a type II RIP, is an AB type toxin, which is one of the most lethal …