Tuberculosis (TB) remains a worldwide problem. Despite the high disease rate, not all who
are infected with Mycobacterium Tuberculosis (Mtb) develop disease. Interferon-γ (IFN-γ) …

Natural history studies of tuberculosis (TB) have revealed a spectrum of clinical outcomes
after exposure to Mycobacterium tuberculosis, the cause of TB. Not all individuals exposed …

Rationale Healthy household contacts (HHC) of individuals with Tuberculosis (TB) with
Tuberculin Skin Test (TST) conversions are considered to harbor latent Mycobacterium …

Background A mechanistic understanding of uncommon immune outcomes such as
resistance to infection has led to the development of novel therapies. Using gene level …

Mycobacterium tuberculosis is a leading cause of mortality worldwide and establishes a
long-lived latent infection in a substantial proportion of the human population. Multiple lines …

The most common test to identify latent tuberculosis is the tuberculin skin test that detects T
cell responses of delayed type hypersensitivity type IV. Since it produces false negative …

Heavy exposure to Mycobacterium tuberculosis, the etiologic agent of tuberculosis (TB) and
among the top infectious killers worldwide, results in infection that is cleared, contained, or …

Resistance to M. tuberculosis, often referred to as “RSTR” in the literature, is being
increasingly studied because of its potential relevance as a clinical outcome in vaccine …

Background Currently, diagnosis of latent TB infection (LTBI) is based on the secretion of
IFN-γ in response to Mycobacterium tuberculosis (Mtb) antigens, the absence of which is …

Certain individuals are able to resist Mycobacterium tuberculosis infection despite persistent
and intense exposure. These persons do not exhibit adaptive immune priming as measured …