Bony defects in the craniomaxillofacial skeleton remain a major and challenging health
concern. Surgeons have been trying for centuries to restore functionality and aesthetic …

Current reconstructive approaches to large craniofacial skeletal defects are often
complicated and challenging. Critical-sized defects are unable to heal via natural …

Conditions such as congenital anomalies, cancers, and trauma can all result in devastating
deficits of bone in the craniofacial skeleton. This can lead to significant alteration in function …

Over the past decades, there has been a substantial amount of innovation and research into
tissue engineering and regenerative approaches for the craniofacial region. This highly …

Craniofacial bone defects can result from various disorders, including congenital
malformations, tumor resection, infection, severe trauma, and accidents. Successfully …

Craniofacial fractures and bony defects are common causes of morbidity and contribute to
increasing health care costs. Successful regeneration of bone requires the concomitant …

Regeneration of normal shape, architecture, and function of craniofacial tissues following
congenital abnormality, trauma, or surgical treatment presents special problems to tissue …

Engineering craniofacial bone tissues is challenging due to their complex structures. Current
standard autografts and allografts have many drawbacks for craniofacial bone tissue …

Bone defects resulting from congenital anomalies, trauma, metabolic diseases, infections,
and tumor removal are formidable clinical challenges for orthopedics and craniofacial …

Translational biomaterials targeted toward the regeneration of large bone defects in the
mandible require a preclinical model that accurately recapitulates the regenerative …