Increased oxygen consumption following activation of brain: theoretical footnotes using spectroscopic data from barrel cortex

J Mayhew, D Johnston, J Martindale, M Jones… - Neuroimage, 2001 - Elsevier
Optical imaging spectroscopy (OIS) and laser Doppler flowmetry (LDF) data sequences from
anesthetized rats were used to determine the relationship between changes in oxy-and …

Changes in blood flow, oxygenation, and volume following extended stimulation of rodent barrel cortex

M Jones, J Berwick, J Mayhew - Neuroimage, 2002 - Elsevier
Simultaneous optical imaging spectroscopy and laser–Doppler flowmetry were used in
rodent barrel cortex to examine the hemodynamic response to extended electrical …

A three-compartment model of the hemodynamic response and oxygen delivery to brain

Y Zheng, D Johnston, J Berwick, D Chen, S Billings… - Neuroimage, 2005 - Elsevier
We describe a mathematical model linking changes in cerebral blood flow, blood volume
and the blood oxygenation state in response to stimulation. The model has three …

Spectroscopic analysis of neural activity in brain: increased oxygen consumption following activation of barrel cortex

J Mayhew, D Johnston, J Berwick, M Jones, P Coffey… - Neuroimage, 2000 - Elsevier
This research investigates the hemodynamic response to stimulation of the barrel cortex in
anaesthetized rats using optical imaging and spectroscopy (Bonhoeffer and Grinvald, 1996; …

A theoretical model of oxygen delivery and metabolism for physiologic interpretation of quantitative cerebral blood flow and metabolic rate of oxygen

T Hayashi, H Watabe, N Kudomi… - Journal of Cerebral …, 2003 - journals.sagepub.com
The coupling of cerebral blood flow (CBF) and metabolic rate of oxygen (CMRO2) during
physiologic and pathophysiologic conditions remains the subject of debate. In the present …

A model of the hemodynamic response and oxygen delivery to brain

Y Zheng, J Martindale, D Johnston, M Jones, J Berwick… - Neuroimage, 2002 - Elsevier
A recent nonlinear system by Friston et al.(2000. NeuroImage 12: 466–477) links the
changes in BOLD response to changes in neural activity. The system consists of five …

The effects of transit time heterogeneity on brain oxygenation during rest and functional activation

PM Rasmussen, SN Jespersen… - Journal of Cerebral …, 2015 - journals.sagepub.com
The interpretation of regional blood flow and blood oxygenation changes during functional
activation has evolved from the concept of 'neurovascular coupling', and hence the …

Blood flow and oxygen delivery to human brain during functional activity: theoretical modeling and experimental data

MA Mintun, BN Lundstrom, AZ Snyder… - Proceedings of the …, 2001 - National Acad Sciences
Coupling of cerebral blood flow (CBF) and cerebral metabolic rate for oxygen (CMRO2) in
physiologically activated brain states remains the subject of debates. Recently it was …

Mathematical model of oxygen transport in the cerebral cortex

AG Hudetz - Brain research, 1999 - Elsevier
To estimate the magnitude of hyperemia necessary to support oxidative metabolism in the
cerebral cortex during functional activation, a mathematical model of O2 transport from …

Linear coupling between cerebral blood flow and oxygen consumption in activated human cortex

RD Hoge, J Atkinson, B Gill… - Proceedings of the …, 1999 - National Acad Sciences
The aim of this study was to test the hypothesis that, within a specific cortical unit, fractional
changes in cerebral blood flow (CBF) and cerebral metabolic rate of oxygen consumption …