Administration of formalin in rat paws results in stimulation of nociceptive pathways, which
leads to an increase in the excitability of neurons present in dorsal horn. This increased …

The non-steroidal anti-inflammatory drug celecoxib has long been used for reducing pain, in
spite of moderate gastrointestinal side effects. In previous studies, it has been shown that …

In a model of peripherally induced inflammatory pain in rats, selective inhibitors of
cyclooxygenase (COX)-2 raised nociceptive thresholds above basal values, an effect …

Nociception evoked prostaglandin (PG) release in the spinal cord considerably contributes
to the induction of hyperalgesia and allodynia. To evaluate the relative contribution of …

Celecoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) and blocks prostaglandin
(PG) biosynthesis associated with inflammatory conditions. In a model of peripherally …

Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits
cyclooxygenase-2 (COX-2). Like most NSAIDs, celecoxib exhibits analgesic effects in …

It is well‐established that inhibitors of cyclo‐oxygenase (COX) and hence of prostaglandin
(PG) biosynthesis reverse inflammatory hyperalgesia and oedema in both human and …

Prostaglandins (PGs) are known to be involved in inflammatory and nociceptive processing.
Since the discovery of at least two isozymes of cyclooxygenase (COX), inhibition of COX-2 …

Non-steroidal antiinflammatory drugs (NSAIDs) are known to induce analgesia mainly via
inhibition of cyclooxygenase (COX). Although the inhibition of COX in the periphery is …

The present study was undertaken to determine the effects of cyclooxygenase (COX)
inhibitors on the development of neuropathic pain in rats following chronic constriction injury …