Treatment advances over the past 25 years have significantly decreased morbidity and
mortality in children with sickle cell disease. Aggressive management of fever, early …

Sickle cell disease results in significant morbidity and mortality for those affected with this
disease. Despite the fact that every case of sickle cell disease results from the same genetic …

Much progress has been made during the past 20 years in the treatment of sickle cell
disease. Identification of most affected infants by neonatal screening provides opportunities …

The familial pattern of recurring pain and early death seen so often among those affected by
sickle cell disease has been long recognized within African cultures, though its first clear …

Sickle cell disease is enormously variable in its expression and outcome. In addition to this
intrinsic variability are the problems of symptomatic selection biasing observations towards …

Sickle cell disease (SCD) is a serious and life-threatening disease that affects approximately
1 in 600 African Americans [1, 2]. In 1910, Herrick described the first patient with SCD, and …

Sickle cell disease is transmitted as an autosomal recessive trait. Symptoms of pallor, fever,
abdominal and joint pain, and swelling of the liver, spleen, hands and feet first appear near …

Serves as a guide for the health care worker involved in the management of patients with
sickle cell disease. Represents a collective summary of experiences with therapeutic …

Over the past few decades, the life expectancy of patients with sickle cell disease has
improved. This has been because of better supportive care and greater awareness of the …

The first clinical description of sickle cell anemia was published in 1910 by Herri~ k?~ who
reported some of the clinical and hematologic manifestations of the disorder in a 20-year-old …