Tsc1 Regulates the Balance Between Osteoblast and Adipocyte Differentiation Through Autophagy/Notch1/β‐Catenin Cascade
HK Choi, H Yuan, F Fang, X Wei, L Liu… - Journal of Bone and …, 2018 - academic.oup.com
ABSTRACT A reduction in trabecular bone mass is often associated with an increase in
marrow fat in osteoporotic bones. The molecular mechanisms underlying this inverse …
marrow fat in osteoporotic bones. The molecular mechanisms underlying this inverse …
[HTML][HTML] The wnt/β-catenin signaling pathway inhibits osteoporosis by regulating the expression of TERT: An in vivo and in vitro study
Y Cai, H Sun, X Song, J Zhao, D Xu, M Liu - Aging (Albany NY), 2023 - ncbi.nlm.nih.gov
Our study was performed to investigate whether the Wingless and int-1 (Wnt) signaling
pathway promotes osteogenic differentiation and inhibits apoptosis in bone marrow …
pathway promotes osteogenic differentiation and inhibits apoptosis in bone marrow …
[HTML][HTML] Tensin-3 is involved in osteogenic versus adipogenic fate of human bone marrow stromal cells
S Zhang, J van de Peppel, M Koedam… - Cellular and Molecular …, 2023 - Springer
Background The tightly controlled balance between osteogenic and adipogenic
differentiation of human bone marrow-derived stromal cells (BMSCs) is critical to maintain …
differentiation of human bone marrow-derived stromal cells (BMSCs) is critical to maintain …
Loss of wnt/β‐catenin signaling causes cell fate shift of preosteoblasts from osteoblasts to adipocytes
L Song, M Liu, N Ono, FR Bringhurst… - Journal of Bone and …, 2012 - academic.oup.com
Wnt signaling is essential for osteogenesis and also functions as an adipogenic switch, but it
is not known if interrupting wnt signaling via knockout of β‐catenin from osteoblasts would …
is not known if interrupting wnt signaling via knockout of β‐catenin from osteoblasts would …
TSC1 regulates osteoclast podosome organization and bone resorption through mTORC1 and Rac1/Cdc42
S Xu, Y Zhang, J Wang, K Li, K Tan, K Liang… - Cell Death & …, 2018 - nature.com
Reorganization of the podosome into the sealing zone is crucial for osteoclasts (OCLs) to
resorb bone, but the underlying mechanisms are unclear. Here, we show that tuberous …
resorb bone, but the underlying mechanisms are unclear. Here, we show that tuberous …
[HTML][HTML] CathepsinKCre mediated deletion of βcatenin results in dramatic loss of bone mass by targeting both osteoclasts and osteoblastic cells
P Ruiz, M Martin-Millan, MC Gonzalez-Martin… - Scientific Reports, 2016 - nature.com
It is well established that activation of Wnt/βcatenin signaling in the osteoblast lineage leads
to an increase in bone mass through a dual mechanism: increased osteoblastogenesis and …
to an increase in bone mass through a dual mechanism: increased osteoblastogenesis and …
Adipocytes derived from human bone marrow mesenchymal stem cells exert inhibitory effects on osteoblastogenesis
H Zhang, W Lu, Y Zhao, P Rong, R Cao… - Current Molecular …, 2011 - ingentaconnect.com
The infiltration of adipocytes in osteoporotic patients' bone marrow suggests an important
regulatory function of bone marrow fat on the development of aged bone. Therefore, we …
regulatory function of bone marrow fat on the development of aged bone. Therefore, we …
Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanism
WP Cawthorn, AJ Bree, Y Yao, B Du, N Hemati… - Bone, 2012 - Elsevier
Wnt10b is an established regulator of mesenchymal stem cell (MSC) fate that inhibits
adipogenesis and stimulates osteoblastogenesis, thereby impacting bone mass in vivo …
adipogenesis and stimulates osteoblastogenesis, thereby impacting bone mass in vivo …
β‐catenin preserves the stem state of murine bone marrow stromal cells through activation of EZH2
B Sen, CR Paradise, Z Xie, J Sankaran… - Journal of Bone and …, 2020 - academic.oup.com
During bone marrow stromal cell (BMSC) differentiation, both Wnt signaling and the
development of a rigid cytoskeleton promote commitment to the osteoblastic over …
development of a rigid cytoskeleton promote commitment to the osteoblastic over …
[HTML][HTML] TM9SF4 is a novel regulator in lineage commitment of bone marrow mesenchymal stem cells to either osteoblasts or adipocytes
L Yu, M Xie, F Zhang, C Wan, X Yao - Stem Cell Research & Therapy, 2021 - Springer
Background Osteoporosis is a common bone disease in elderly population caused by
imbalanced bone formation and bone resorption. Mesenchymal stem cells (MSCs) are …
imbalanced bone formation and bone resorption. Mesenchymal stem cells (MSCs) are …