ABSTRACT A reduction in trabecular bone mass is often associated with an increase in
marrow fat in osteoporotic bones. The molecular mechanisms underlying this inverse …

Our study was performed to investigate whether the Wingless and int-1 (Wnt) signaling
pathway promotes osteogenic differentiation and inhibits apoptosis in bone marrow …

Background The tightly controlled balance between osteogenic and adipogenic
differentiation of human bone marrow-derived stromal cells (BMSCs) is critical to maintain …

Wnt signaling is essential for osteogenesis and also functions as an adipogenic switch, but it
is not known if interrupting wnt signaling via knockout of β‐catenin from osteoblasts would …

Reorganization of the podosome into the sealing zone is crucial for osteoclasts (OCLs) to
resorb bone, but the underlying mechanisms are unclear. Here, we show that tuberous …

It is well established that activation of Wnt/βcatenin signaling in the osteoblast lineage leads
to an increase in bone mass through a dual mechanism: increased osteoblastogenesis and …

The infiltration of adipocytes in osteoporotic patients' bone marrow suggests an important
regulatory function of bone marrow fat on the development of aged bone. Therefore, we …

Wnt10b is an established regulator of mesenchymal stem cell (MSC) fate that inhibits
adipogenesis and stimulates osteoblastogenesis, thereby impacting bone mass in vivo …

During bone marrow stromal cell (BMSC) differentiation, both Wnt signaling and the
development of a rigid cytoskeleton promote commitment to the osteoblastic over …

Background Osteoporosis is a common bone disease in elderly population caused by
imbalanced bone formation and bone resorption. Mesenchymal stem cells (MSCs) are …