Mammalian gap junction proteins, connexins, have long been implicated in tumor
suppression. Recently, a novel family of proteins named pannexins has been identified as …

Connexins (Cxs), the gap junction proteins, have been found to be downregulated in many
types of cancers including gliomas. By restoring gap junctional communication in cancer cell …

Pannexins are mammalian orthologs of the invertebrate gap junction proteins innexins and
thus have been proposed to play a role in gap junctional intercellular communication …

Until recently, members of the connexin gene family were believed to comprise the sole
molecular component forming gap junction channels in vertebrates. The recent discovery of …

Pannexins are a newly described family of proteins that may form gap junctions. We made
antisera against mouse pannexin1 (Panx1). HeLa cells expressing Panx1 have cell surface …

Gap junctions (GJs) are composed of proteins that form a channel connecting the cytoplasm
of adjacent cells. Connexins were initially considered to be the only proteins capable of GJ …

Connexins had been considered to be the only class of the vertebrate proteins capable of
gap junction formation; however, new candidates for this function with no homology to …

We have cloned the genes PANX1, PANX2 and PANX3, encoding putative gap junction
proteins homologous to invertebrate innexins, which constitute a new family of mammalian …

Since their characterization more than five decades ago, gap junctions and their structural
proteins—the connexins—have been associated with cancer cell growth. During that period …

The gap junction in vertebrates is encoded by the connexin gene family. Recently, a new
gene family termed pannexin (Panx) has been identified in vertebrates and found to encode …