Isodon rubescens has been used as a traditional green tea for more than 1000 years and
many medicinal functions of I. rubescens are also very useful, such as its well-known …

Oridonin belongs to ent-kaurane tetracyclic diterpenoid and was first isolated from Isodon
species. It exhibits inhibitory activities against a variety of tumor cells, and pharmacological …

The biological function of the natural ent-kaurene diterpenoid isolated from genus Isodon,
oridonin, has been intensively studied. However, its mechanism studies and clinical …

A series of novel spirolactone-type diterpenoid derivatives of oridonin (12a–j) were
designed and synthesized. All the target compounds showed improved anti-proliferative …

Two series of derivatives with 1, 2, 3-triazole as heterocyclic moiety of Jiyuan Oridonin A, a
new ent-kaurene diterpenoid which was isolated from genus Isodon rubescens, were …

The cytotoxicity of the natural ent-kaurene diterpenoid, oridonin, has been extensively
studied. However, the application of oridonin for cancer therapy was hampered primarily by …

Oridonin, a diterpenoid isolated from Rabdosia rubescens (Hemsl.) Hara, has been proved
to possess remarkable anticancer activity, in addition to its potential in antiinflammation and …

A series of enmein-type diterpenoid analogs (11–20) derived from natural kaurene-type
diterpenoid oridonin were synthesized and biologically evaluated. All target compounds …

Abstract Jiyuan Oridonin A (JOA) is a naturally occurring ent-kaurane diterpenoid that
exhibits significant potential in the field of anti-tumor drug development. However, its …

Oridonin (1), an active component isolated from the plant Rabdosia rubescens, has been
reported to exhibit antitumor effects. In this study, the mechanism involved in 1-induced …